2024
DOI: 10.1038/s42003-024-07171-9
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Knowledge-based inductive bias and domain adaptation for cell type annotation

Zhenchao Tang,
Guanxing Chen,
Shouzhi Chen
et al.

Abstract: Measurement techniques often result in domain gaps among batches of cellular data from a specific modality. The effectiveness of cross-batch annotation methods is influenced by inductive bias, which refers to a set of assumptions that describe the behavior of model predictions. Different annotation methods possess distinct inductive biases, leading to varying degrees of generalizability and interpretability. Given that certain cell types exhibit unique functional patterns, we hypothesize that the inductive bia… Show more

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