Long‐term research is essential for guiding the development of agroecosystems to meet escalating production demands in a manner that is environmentally sound and socially acceptable. Research must integrate biophysical and socioeconomic factors to provide geographically scalable knowledge that involves stakeholders across the research‐education‐extension‐policy spectrum. In response to this need, the Long‐Term Agroecosystem Research (LTAR) network developed a “Common Experiment,” which seeks to develop and disseminate multi‐region, science‐based information to enable implementation of visionary agricultural innovations while simultaneously promoting food security, well‐being, environmental quality, and climate adaptation and mitigation. The core design of the Common Experiment contrasts prevailing and alternative/aspirational production systems, with the latter including novel innovations hypothesized to advance sustainable intensification in locally appropriate ways. Treatments in the Common Experiment represent a diversity of production systems under cropland, grazing land, and integrated crop/grazing land management. Where possible, treatments are evaluated at multiple spatial scales (e.g., from plot to enterprise) and are designed to evolve over the course of the experiment with stakeholder input. A common assessment framework guides data collection for the experiment and is complemented by metric‐specific protocols and an emerging data management infrastructure. Currently, there are large differences among sites in the application of the experimental framework and degree of stakeholder engagement; differences largely grounded in pragmatic issues related to land access, site expertise, and resource availability. The full potential of the LTAR Common Experiment may be realized with strategic investments in network capacity.