Knowledge Domain and Hotspots Predict Concerning Electroactive Biomaterials Applied in Tissue Engineering: A Bibliometric and Visualized Analysis From 2011 to 2021

Abstract

Objective: Electroactive biomaterials used in tissue engineering have been extensively studied. Electroactive biomaterials have unique potential advantages in cell culture and tissue regeneration, which have attracted the attention of medical researchers worldwide. Therefore, it is important to understand the global scientific output regarding this topic. An analysis of publications on electroactive biomaterials used in tissue engineering over the past decade was performed, and the results were summarised to track the current hotspots and highlight future directions.Methods: Globally relevant publications on electroactive biomaterials used in tissue engineering between 2011 and 2021 were extracted from the Web of Science database. The VOSviewer software and CiteSpace were employed to visualise and predict trends in research on the topic.Results: A total of 3,374 publications were screened. China contributed the largest number of publications (995) and citations (1581.95, actual value ×0.05). The United States achieved the highest H-index (440 actual values ×0.05). The journal Materials Science & Engineering C-materials for Biological Applications (IF = 7.328) published the most studies on this topic (150). The Chinese Academy of Science had the largest number of publications (107) among all institutions. The publication titled Nanotechnological strategies for engineering complex tissues by Dir, T of the United States had the highest citation frequency (985 times). Regarding the function of electroactive materials, the keyword “sensors” emerged in recent years. Regarding the characterisation of electroactive materials, the keyword “water contact angle” appeared lately. Regarding electroactive materials in nerve and cardiac tissue engineering, the keywords “silk fibroin and conductive hydrogel” appeared recently. Regarding the application of electroactive materials in bone tissue engineering, the keyword “angiogenesis” emerged in recent years. The current research trend indicates that although new functional materials are constantly being developed, attention should also be paid to their application and transformation in tissue engineering.Conclusion: The number of publications on electroactive biomaterials used in tissue engineering is expected to increase in the future. Topics like sensors, water contact angle, angiogenesis, silk fibroin, and conductive hydrogels are expected to be the focuses of research in the future; attention should also be paid to the application and transformation of electroactive materials, particularly bone tissue engineering. Moreover, further development of the field requires joint efforts from all disciplines.

Bibliometric and visualization analysis of macrophages associated with osteoarthritis from 1991 to 2021

“…The time curve of publications was drawn according to previous article ( 19 ). The H-index, which refers to a scholar who has published H papers and they have been cited at least H times, was defined to measure the impact of scientific research ( 27 ). We chose the VOSviewer (Leiden University, Leiden, The Netherlands) software to construct and visualize bibliometric networks of the publications in our present study.…”

Worldwide productivity and research trend of publications concerning electroactive materials and spinal cord injury: A bibliometric study

“…Bibliometrix is a scientific bibliometric software developed by Federico II University of Naples, Italy, using the R programming language. Consistent with past research, the R 4.0.3 bibliometrix program is used to automatically transform and evaluate publication data (Huang et al, 2022;Xiong et al, 2022). The research contains the number of publications each year, the number of publications by nation, an analysis of authors and institutions, an analysis of journals, co-cited references, and important terms.…”

“…Among them, hydrogels are widely used for SCI repair due to their hydrophilicity and biocompatibility, such as drug delivery, lubrication, conductive coating of nerve electrode, etc., (Wang et al, 2022). Piezoelectric materials may generate an electrical charge in reaction to mechanical deformation and undergo mechanical deformation in response to an applied electric field; simultaneously, piezoelectric effects can modify cellular function and regulate the growth and remodeling of bone tissue and axon guidance (Tandon et al, 2018;Dai et al, 2022;Xiong et al, 2022). In particular, polylactic acid (PLLA) has good piezoelectric properties and the ability to carry conductive polymers that mimic the extracellular matrix, maintain cell stemness and promote axon guidance (Dai et al, 2022).…”

Knowledge mapping concerning applications of nanocomposite hydrogels for drug delivery: A bibliometric and visualized study (2003–2022)

“…Information visualization based on computer science is one of the significant developments of bibliometrics, researchers can have a concrete and intuitive understanding of specific research fields through information networks and maps (Gonzalez-Alcaide et al, 2017). Bibliometrics has become a powerful tool for people to quickly grasp the scope and theme, history and current situation, frontiers and trends of a certain scientific research field, which has been widely used in many fields and achieved a lot of research results (Qi-Qi et al, 2016;Ke et al, 2020;Liu T. et al, 2021;Dong et al, 2022;Xiong et al, 2022). However, the bibliometric and visualized analysis for NHs is still lacking, especially their applications in drug delivery system.…”