Knowledge Mapping of Migraine: a Bibliometric Analysis (2000-2019)

Abstract

Background: There has been rapid development of migraine research in the past 20 years in China and around the world. We analyzed the development trend of migraine research, and made a bibliometric analysis on the growth trend of the total number of publications, countries, institutions, authors, cited references and keywords from 2000 to 2009 and 2010 to 2019 by applying visualization software, and constructed the relevant knowledge map, and found the trends and hot spots in the field through comparison. Methods: Retrieved the literature on migraine in the Web of Science database from 2000-2009 and 2010-2019 respectively, and then utilized CiteSpace to conduct bibliometric analysis to acquire the knowledge mapping. Results: The total number of publications each year has increased year by year, and the average annual growth rate from 2000 to 2009 was 7.999%, while from 2010 to 2019 was 5.348%, with a faster growth rate from 2000 to 2009. According to the cluster analysis of institutions, authors, cited references, and keywords, 10/11, 12/11, 12/11, and 8/9 categories were obtained from 2000 to 2009 and 2010 to 2019 respectively. The most productive countries, institutions, and authors are the USA, Albert Einstein College of Medicine, and Lipton RB from 2000 to 2009 and 2010 to 2019, whose frequency is 4274/7107, 322/592, and 279/472 respectively. However, the most important of them are Belgium/ Pakistan, Houston Headache Clin/ Amgen Inc, and Lipton RB/ Klatt J, owing to their highest centrality, they are 1.20/1.08, 1.13/1.32, and 1.22/0.89 separately. Moreover, Cited references that contributed to the most co-citations are Silberstein SD (2004)/ Bes A (2013) from 2000 to 2009 and 2010 to 2019, however, the most vital cited reference is Welch KMA (2001)/ Goadsby PJ (2017). Keywords such as migraine, headache, prevalence, and the double blind are the most frequently used. But prevalence is the crucial keyword. In the cluster analysis of institutions, authors, cited references, and keywords from 2000 to 2009 and 2010 to 2019, the more convincing research categories are potential anti-migraine agent/ chronic migration prevention, reducing headache recurrence/ following symptomatic treatment, to-left shunt/ placebo controlled phase, spectrum study/ family study hemiplegic migraine, with S values of 0.952/0.956, 0.985/0/986, 0.981/0.970 and 0.985/0.982 respectively. Furthermore, the hotspots in this field are “stimulation”, “triptan” from 2000 to 2009 and 2010 to 2019. Conclusion: Based on the bibliometric analysis in the past 20 years, the knowledge mapping of the country, institution, author, cited reference, and the keyword is gained, which has an important guiding significance for quickly and accurately positioning the trend in this field.