Kocuria kristinae: an emerging pathogen in medical practice

Napolitani, M; Troiano, Gianmarco; Bedogni, C; Messina, Gabriele; Nante, Nicola

doi:10.1099/jmm.0.001023

Cited by 30 publications

(23 citation statements)

References 35 publications

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“…The Gram+coccus bacterium Kocuria was identified as a common inhabitant of skin and oral mucosa (Grice et al, 2008 ). Recently, it was associated with urinary tract infection (Napolitani et al, 2019 ) and with infections in immunocompromised patients (Ma et al, 2005 ; Tsai et al, 2010 ). In line with these findings, we intriguingly observed that Kocuria specie was predominantly present in endometrial samples of non-pregnant women.…”

Section: Resultsmentioning

confidence: 99%

Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility

Riganelli

Iebba

Piccioni

et al. 2020

Front. Cell. Infect. Microbiol.

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Microbiota are microorganismal communities colonizing human tissues exposed to the external environment, including the urogenital tract. The bacterial composition of the vaginal microbiota has been established and is partially related to obstetric outcome, while the uterine microbiota, considered to be a sterile environment for years, is now the focus of more extensive studies and debates. The characterization of the microbiota contained in the reproductive tract (RT) of asymptomatic and infertile women, could define a specific RT microbiota associated with implantation failure. In this pilot study, 34 women undergoing personalized hormonal stimulation were recruited and the biological samples of each patient, vaginal fluid, and endometrial biopsy, were collected immediately prior to oocyte-pick up, and sequenced. Women were subsequently divided into groups according to fertilization outcome. Analysis of the 16s rRNA V4-V5 region revealed a significant difference between vaginal and endometrial microbiota. The vaginal microbiota of pregnant women corroborated previous data, exhibiting a lactobacilli-dominant habitat compared to non-pregnant cases, while the endometrial bacterial colonization was characterized by a polymicrobial ecosystem in which lactobacilli were exclusively detected in the group that displayed unsuccessful in vitro fertilization. Overall, these preliminary results revisit our knowledge of the genitourinary microbiota, and highlight a putative relationship between vaginal/endometrial microbiota and reproductive success.

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Section: Resultsmentioning

confidence: 99%

Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility

Riganelli

Iebba

Piccioni

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Arthrobacter was associated with spring, Kocuria and Deinococcus were associated with summer, Acinetobacter was associated with autumn, and Streptococcus was associated with winter. These bacterial taxa have been isolated from the environment as well as animals and physiologically characterized (25)(26)(27)(28)(29)(30)(31)(32). Streptococcus is a common resident of human skin.…”

Section: Discussionmentioning

confidence: 99%

Skin Microbiota of the Captive Giant Panda (Ailuropoda Melanoleuca) and the Distribution of Opportunistic Skin Disease-Associated Bacteria in Different Seasons

et al. 2021

Front. Vet. Sci.

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The giant panda is one of the rarest animals in the world. Skin diseases seriously endanger the health of giant panda and are considered the second major cause of its morbidity. Skin microbiota is a complex ecosystem, and the community structure and the pathogenic potential of bacteria on giant panda skin remain largely unclear. In order to understand the skin bacterial flora of captive giant pandas, the microbiota in giant panda skin samples collected during different seasons was profiled via 16S rRNA gene sequencing. In total, 522 genera from 53 bacterial phyla were detected, with Proteobacteria (40.5%), Actinobacteria (23.1%), Firmicutes (21.1%), Bacteroidetes (9.5%), Cyanobacteria (2.1%), and Thermi (1.2%) as the predominant phyla and Streptococcus (13.9%), Acinetobacter (9.2%), Staphylococcus (2.9%), Pseudomonas (5.9%), Dermacoccus (4.8%), Brachybacterium (2.9%), Escherichia (2.7%), Chryseobacterium (2.1%), Arthrobacter (1.6%), Kocuria (1.5%), Psychrobacter (1.2%), Deinococcus (1.1%), and Flavobacterium (1.1%) as the predominant genera. The results indicated that the diversity was lower in winter than in other seasons and higher in autumn than in other seasons, and the abundance in spring was significantly higher than that in other seasons. Several skin disease-associated bacteria were detected as opportunists in the skin microbiota of healthy giant pandas. In this study, the results indicated that the high diversity and abundance of the skin bacteria may have enhanced the occurrence of skin disease in autumn and spring and that skin disease-associated bacteria are the normal components of the skin microbiota.

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“…Kocuria species are gram‐positive bacteria which are rarely associated with human disease. To date, only 28 patients with Kocuria kristinae infection, the most common pathogenic species, have been reported 20 . These include patients with cholecystitis, peritonitis, abdominal abscess, bacteremia, umbilical sepsis, and urinary tract infection 20,21 .…”

Section: Discussionmentioning

confidence: 99%

“…To date, only 28 patients with Kocuria kristinae infection, the most common pathogenic species, have been reported 20 . These include patients with cholecystitis, peritonitis, abdominal abscess, bacteremia, umbilical sepsis, and urinary tract infection 20,21 . Cardiac involvement in Kocuria infections is very rare and only four patients with Kocuria endocarditis have been reported 20,21,22,23,24 .…”

Section: Discussionmentioning

confidence: 99%

Atypical pathogens associated with cardiac implantable electronic device infections

Kohli

Hazra

Ahmed

et al. 2021

Pacing Clinical Electrophis

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Background Cardiovascular implantable electronic device (CIED) infections are associated with significant morbidity and mortality making the identification of the causative organism critical. The vast majority of CIED infections are caused by Staphylococcal species. CIED infections associated with atypical pathogens are rare and have not been systematically investigated. The objective of this study is to characterize the clinical course, management and outcome in patients with CIED infection secondary to atypical pathogens. Methods Medical records of all patients who underwent CIED system extraction at the University of Chicago Medical Center between January 2010 and November 2020 were retrospectively reviewed to identify patients with CIED infection. Demographic, clinical, infection‐related and outcome data were collected. CIED infections were divided into typical and atypical groups based on the pathogens isolated. Results Among 356 CIED extraction procedures, 130 (37%) were performed for CIED infection. Atypical pathogens were found in 5.4% (n = 7) and included Pantoea species (n = 2), Kocuria species (n = 1), Cutibacterium acnes (n = 1), Corynebacterium tuberculostearicum (n = 1), Corynebacterium striatum (n = 1), Stenotrophomonas maltophilia (n = 1), and Pseudozyma ahidis (n = 1). All patients with atypical CIED infections were successfully treated with total system removal and tailored antibiotic therapy. There were no infection‐related deaths. Conclusions CIED infections with atypical pathogens were rare and associated with good outcome if diagnosed early and treated with total system removal and tailored antimicrobial therapy. Atypical pathogens cultured from blood, tissue or hardware in patients with CIED infection should be considered pathogens and not contaminants.

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Kocuria kristinae: an emerging pathogen in medical practice

Cited by 30 publications

References 35 publications

Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility

Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility

Skin Microbiota of the Captive Giant Panda (Ailuropoda Melanoleuca) and the Distribution of Opportunistic Skin Disease-Associated Bacteria in Different Seasons

Atypical pathogens associated with cardiac implantable electronic device infections

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