Koebner phenomenon from insulin injection

Madhavan, Parvathy; Hamann, L Kelly; Shoukri, Kamal; Dulipsingh, Latha

doi:10.3949/ccjm.88a.20076

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The intradermal injection of insulin and antigens has been shown to induce the Koebner phenomenon in the psoriasis model but has been rarely reported in vitiligo. 8 Hedges et al 9 reported the first case of intradermal insulin injection–induced vitiligo and lipohypertrophy. Chemical leukoderma is a condition in which the chemical substance of a particular product induces the loss of pigment in the contact area.…”

Section: Discussionmentioning

confidence: 99%

Vitiligo associated with polycaprolactone-based collagen stimulator filler

Huang

2022

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Vitiligo associated with polycaprolactone-based collagen stimulator filler

Huang

2022

JAAD Case Reports

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“…Needle acupuncture [130] Radiotherapy [131][132][133][134][135] Cupping therapy [136,137] Hirudotherapy [138] Specific Immunotherapy [139] Pulsed dye laser [140] Laser hair removal [141,142] Platelet-rich plasma injection [143] Subcutaneous Methotrexate/ Insulin Injection [144][145][146] Purified protein derivative (PPD)/ Mantoux test [31,147,148] Ayurveda [149] Colostomy Bag [150] Hair transplantation/ skin grafting [151,152] Mohs micrographic surgery [111] Electrocardiogram electrode negative pressure suction [153] Secondary to other diseases…”

Section: Vaccination [129]mentioning

confidence: 99%

Characteristics and pathogenesis of Koebner phenomenon

Zhang

Jiang

et al. 2022

Experimental Dermatology

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The Koebner phenomenon, also known as isomorphic reaction, refers to the development of secondary lesions with the same clinical manifestations and histopathological characteristics as the primary lesions in normal skin after trauma or other stimuli. The triggering factors of Koebner phenomenon include physical trauma, chemical stimulation, mechanical stress, iatrogenic stimulation and pathogenic infection. Vitiligo, psoriasis and lichen planus are considered true Koebner phenomenon. Recent studies have shown that immunological disorders, oxidative stress, defective melanocyte adhesion and growth factor deficiency are the main pathological mechanisms of vitiligo Koebner phenomenon. In psoriasis, triggers may drive skin inflammation to induce a psoriatic phenotype through multiple signalling pathways and thereby cause Koebner phenomenon in susceptible individuals. Significantly, keratinocytes mediate the occurrence of Koebner phenomenon in psoriasis through mechano‐induced signalling pathways after sensing mechanical signals and explains the high frequency of psoriasis lesions on the extensor side of the elbow and knee joints. On the contrary, TRPA1‐driven mechano‐transduction, autoimmunity and actinic damage are the underlying mechanisms of Koebner phenomenon in lichen planus. In this review, we have summarized the current understanding of the characteristics and pathogenesis of Koebner phenomenon.

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Koebnerization From Insulin Pump and Continuous Glucose Monitor in a Patient With Psoriasis

Dagenet

Hamann

2023

Dermatitis®

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Koebner phenomenon from insulin injection

Cited by 3 publications

References 5 publications

Vitiligo associated with polycaprolactone-based collagen stimulator filler

Vitiligo associated with polycaprolactone-based collagen stimulator filler

Characteristics and pathogenesis of Koebner phenomenon

Koebnerization From Insulin Pump and Continuous Glucose Monitor in a Patient With Psoriasis

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