Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells

Abstract

Adiponectin (APN), released mainly from adipose tissue, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity. A recent study showed that human hair follicles express APN receptors and the presence of APN-mediated hair growth signaling, thereby suggesting that APN is a potent hair growth-promoting adipokine. Previously, kojyl cinnamate ester derivatives (KCEDs) were synthesized in our institute as new anti-aging or adiponectin-/adipogenesis-inducing compounds. Here, we tested the activity of these derivatives to induce endogenous APN secretion. Among the derivatives, KCED-1 and KCED-2 showed improved activity in inducing APN mRNA expression, secretion of APN protein, and adipogenesis in human subcutaneous fat cells (hSCFs) when compared with the effects of Seletinoid G, a verified APN inducer. When human follicular dermal papilla cells were treated with the culture supernatant of KCED-1- or KCED-2-treated hSCFs, the mRNA expression of APN-induced hair growth factors such as insulin-like growth factor, hepatocyte growth factor, and vascular endothelial growth factor was upregulated compared with that in the control. Taken together, our study shows that among kojyl cinnamate ester derivatives, KCED-1, KCED-2, as well as Seletinoid G are effective inducers of endogenous APN production in subcutaneous fat tissues, which may in turn contribute to the promotion of hair growth in the human scalp.

Growth performance, nucleic acids, leptin and adiponectin and their receptor gene expression were significantly affected by feeding different lipid supplementation in GIFT tilapia juveniles

“…Adiponectin mainly plays its role through adiponectin receptors 1 and 2 (AdipoRs 1 & 2) (Wang et al., 2017; Yamauchi et al., 2014; Yang et al., 2018). Dietary fatty acid composition and excessive deposition of body fat can affect adiponectin secretion and AdipoR 1 & 2 expression, and then affect lipid metabolism and energy metabolism (Geng et al., 2016; Holland et al., 2017; Park & Cho, 2019; Sobolesky et al., 2016).…”

Mechanisms of Adiponectin Action

“…Park et al report that kojyl cinnamate ester derivatives and Seletinoid G promote adiponectin secretion by human follicular dermal papilla cells. In addition, cell medium containing secreted adiponectin induces the expression of hair growth-related factors, thus suggesting an involvement of the hormone in the promotion of hair growth in humans [14]. Finally, Okura et al investigate the interaction between adiponectin and NGFβ and SPARC.…”

RNA sequence analysis of dermal papilla cells’ regeneration in 3D culture

“…Recently, the rates of hair loss among adults are on the rise, and limited treatment options are available for such patients 25,26 . Most studies confirmed that the dermal papilla cells (DPCs) cause ageing of hair follicles 27,28 . With age, the hair follicle becomes old, and the mitotic capacity of cells worsen.…”