Komplikationsprophylaxe nach abdominalchirurgisch-urologischen Eingriffen durch Plasmaproteinsubstitution

Bauer, H.; Mayer, P.; Schmiedt, E

doi:10.1159/000221644

Cited by 1 publication

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“…However, the importance of physiologic albumin and serum protein levels is questionable. Low serum protein concentrations are supposed to induce more complications postoperatively [17,38,39]; however, the outcome concerning mortality is obviously not reduced [40]. Although the concentration of the serum electrolytes (Na, K, and Cl) was similar in all groups the serum calcium concentration was significantly higher in the Biseko Ò and Albumin group probably due to the different serum protein levels.…”

Section: Discussionmentioning

confidence: 99%

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Perioperative Application of a Serum Protein Solution (Biseko®) After Proximal Femur Fracture of Elder Patients

Maier

Reinert

Lehnert

et al. 2007

Eur J Trauma Emerg Surg

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Fractures of the proximal femur are frequently seen in elderly people and will increase due to the demographic development of most industrialized countries. Early operation of dislocated fractures with either osteosynthesis or hemiprothesis has become a standard treatment for this type of injury. The high co-morbidity often leads to secondary complications like infections still resulting in a perioperative mortality rate of 11%. The perioperative infusion regime might influence the postoperative inflammatory response. Therefore Biseko(®), a serum protein solution, was compared to albumin and crystalloid infusion (Elomel). A total of 45 patients with proximal femur fractures were randomly assigned to either of the groups and received 500 ml of the infusion on 3 days starting from the day of operation. The Biseko(®) group showed significantly lower CRP levels, less infections and antibiotic treatment as well as a better clinical outcome referring to the TISS28 and APACHE Score. Concerning IL-6, IL-8, IL-10 and serum leukocytes no significant differences were observed. The result shows a beneficial influence of the serum protein solution Biseko(®) concerning the number of perioperative complications. The design of this study and the small number of patients does not yet allow any conclusion concerning the effectiveness of this treatment.

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Section: Discussionmentioning

confidence: 99%

“…Also less broncho-pulmonal complications occurred in the group treated with Biseko Ò than in the control group after abdominal operation [17]. In recent years the therapeutic indications of Biseko Ò have been limited due to its plasma-derived risks and comparably high price.…”

Section: Introductionmentioning

confidence: 98%