Kondogogu gum-Zn+2-pectinate emulgel matrices reinforced with mesoporous silica for intragastric furbiprofen delivery

Bera, Hriday; Nadimpalli, Jhansirani; Kumar, Sanoj; Vengala, Pavani

doi:10.1016/j.ijbiomac.2017.07.027

Cited by 38 publications

(8 citation statements)

References 29 publications

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“…Moreover, the XRD patterns of these 2 samples do not show any kind of sharp peaks and this serves as an evidence for amorphous nature of the agar gel and squalene-loaded emulgel scaffold. [26][27][28] Whereas the presence of squalene in emulgel scaffold formulation was verified by using FTIR spectral analysis. Furthermore, the results acquired from FTIR spectroscopy also showed that agar and squalene interacted considerably.…”

Section: Discussionmentioning

confidence: 99%

“…XRD patterns of freeze-dried agar gels and squalene-loaded emulgels were analyzed using Bruker D8 Advance X-ray diffractometer having the scanning range width (2θ) of about 10 to 80 with a step-width of about 0.003. [24][25][26][27][28]…”

Section: X-ray Diffraction Studymentioning

confidence: 99%

“…Prior to FTIR characterization, samples were freeze-dried for 72 hours and about 1 mg of squalene-loaded emulgel scaffold and agar gels was used for this study. 26,[28][29][30][31][32][33]…”

Section: Ftir Analysismentioning

confidence: 99%

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Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Shanmugarajan

Selvan

Uppuluri

2020

The International Journal of Lower Extremity Wounds

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Full-thickness burns pose a major challenge for clinicians to handle because of their restricted self-healing ability. Even though several approaches have been implemented for repairing these burnt skin tissue defects, all of them had unsatisfactory outcomes. Moreover, during recent years, skin tissue engineering techniques have emerged as a promising approach to improve skin tissue regeneration and overcome the shortcomings of the traditional approaches. Although previous literatures report the wound healing effects of the squalene oil, in the current study, for the first time, we developed a squalene-loaded emulgel-based scaffold as a novel approach for potential skin regeneration. This squalene-loaded agar-based emulgel scaffold was fabricated by using physical cross-linking technique using lecithin as an emulsifier. Characterization studies such as X-ray diffraction, Fourier-transform infrared spectroscopy, and field emission scanning electron microscopy revealed the amorphous nature, chemical interactions, and cross-linked capabilities of the developed emulgel scaffold. The squalene-loaded emulgel scaffold showed excellent wound contraction when compared with the agar gel and negative control. In case of the histopathology and recent immunohistochemistry findings, it was clearly evidenced that squalene-loaded emulgel promoted faster rate of the revascularization and macrophage polarization in order to enhance the burn wound healing. Moreover, the findings also revealed that the incorporation of squalene oil into the formulation enhances collagen deposition and accelerates the burnt skin tissue regeneration process. Finally, we conclude that the squalene-loaded emulgel scaffold could be an effective formulation used in the treatment of the burnt skin tissue defects.

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Section: Discussionmentioning

confidence: 99%

Section: X-ray Diffraction Studymentioning

confidence: 99%

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Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Shanmugarajan

Selvan

Uppuluri

2020

The International Journal of Lower Extremity Wounds

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“…The n value between 0.43 and 0.85 refers to non‐Fickian release. The value of n ≥ 0.85 represents case‐II transport …”

Section: Methodsmentioning

confidence: 99%

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

et al. 2017

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The current study is aimed at developing Plantago ovata F. husk mucilage (PHM)‐blended Zn2+‐crosslinked low methoxyl (LM) pectinate (PHM‐Zn2+‐LM‐pectinate) controlled‐release matrices containing aceclofenac (ACF) for the management of rheumatoid arthritis (RA) in patients with an outright zinc deficiency. The ACF‐encapsulated hydrogel matrices are accomplished by ionic gelation using ZnSO4 as a crosslinker. The matrix diameter ranges from 1.39 ± 0.14 to 1.62 ± 0.16 mm. These formulations demonstrate excellent drug encapsulation efficiency (DEE, 63.80 ± 1.73–90.56 ± 2.72%) and controlled drug‐release behavior over a prolonged period of time (Q10 h, 51.42 ± 3.10 to 92.60 ± 2.38%). The drug‐elution patterns of different matrices are best‐fitted by a zero‐order kinetic model with a case‐II‐transport‐driven mechanism. The matrices also depict pH‐dependent swelling and degradation properties. In addition, the composites are characterized by scanning electron microscopy (SEM), Fourier transform IR (FTIR), and powder X‐ray diffraction (P‐XRD) analyses. Thus, the newly developed PHM‐Zn+2‐LM‐pectinate matrices could be appropriate for controlled ACF delivery along with Zn supplementation in the effective treatment of RA.

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“…To overcome this limitation, emulgels are prepared. When emulsion and gels are combined together, the formulation is termed as emulgel (Bera et al, 2017). The emulgel for dermatological use has various favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non-staining, water soluble, longer shelf life, bio-friendly, pleasing appearance and better stability (Kute and Saudagar, 2013).…”

Section: Introductionmentioning

confidence: 99%

An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel

Sohail

Akhtar

Abdul

et al. 2018

Saudi Pharmaceutical Journal

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Kondogogu gum-Zn+2-pectinate emulgel matrices reinforced with mesoporous silica for intragastric furbiprofen delivery

Cited by 38 publications

References 29 publications

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel

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Kondogogu gum-Zn+2-pectinate emulgel matrices reinforced with mesoporous silica for intragastric furbiprofen delivery

Cited by 38 publications

References 29 publications

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn+2‐Pectinate Controlled‐Release Matrices

An approach to enhanced stability: Formulation and characterization of Solanum lycopersicum derived lycopene based topical emulgel

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Product

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Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices