Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo

Park, Ju-Hyoung; Ahn, Eun‐Kyung; Ko, Hyejin; Lee, Jae Yeon; Hwang, Seung-Mi; Ko, Seon-Mi; Oh, Joa Sub

doi:10.1016/j.biopha.2019.109066

Cited by 22 publications

(13 citation statements)

References 42 publications

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“…Previous studies have shown that the antifibrosis effect of a type of ginsenoside AD-2 extracted from ginseng on thioacetamide-induced liver injury in mice is related to the inflammatory factors (including TNF- α , IL-1 β , caspase-1, and IL-6) associated with hepatic fibrosis [ 32 ]. Korean red ginseng water extract decreased the mRNA expression levels of interleukin-6 (IL-6), thymic stromal lymphopoietin (TSLP), and TNF- α in the 1-chloro-2,4-dinitrobenzene- (DNCB-) induced BALB/c mouse model which develops atopic dermatitis- (AD-) like lesions and alleviates AD-like inflammatory responses [ 33 ]. For liver fibrosis in rats induced by CCl 4 , ginseng extract inhibits liver inflammation by downregulating rat hepatic prostaglandin E 2 and tissue inhibitor metalloproteinase-1 (TIMP-1) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Panax ginseng Extract on Hepatic Dysfunction: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Shen

Gwak

Joo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The purpose of this study was to evaluate the efficacy and safety of Panax ginseng extract (GS-KG9) in the treatment of hepatic dysfunction. Methods. A randomized, double-blind, placebo-controlled clinical trial was conducted from December 2017 to January 2019. The trial included 60 subjects between the ages of 19 and 70 who had higher alanine transaminase (ALT) levels than the normal upper limit. The subjects were randomly divided into two groups: GS-KG9 (n = 30) and placebo (n = 30). The former was administered three GS-KG9 capsules (3 g/day) and the latter three placebo capsules (3 g/day) twice each day orally after meals in the morning and evening for 12 weeks. The primary goal was to observe the changes in ALT and gamma-glutamyl transferase (GGT) levels. The safety of the treatment was assessed and adverse events (AEs) were recorded. Results. Out of 60 subjects, nine were excluded from the efficacy analysis because they met the exclusion criteria. Therefore, a total of 51 subjects were evaluated for the effectiveness of the treatment (26 in the GS-KG9 group and 25 in the placebo group). After 12 weeks of treatment, the ALT levels were significantly reduced in the GS-KG9 group compared to the placebo group (p=0.009). The GGT level of the GS-KG9 group was significantly lower than that of the placebo group (p=0.036). Mild AEs, such as diarrhea, occurred during the study. There were no significant differences between the two groups. Conclusion. The results of this trial suggest that GS-KG9 might be an effective and safe option for mild hepatic dysfunction. This trial is registered with KCT0004080.

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Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Panax ginseng Extract on Hepatic Dysfunction: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Shen

Gwak

Joo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…MAPK signaling pathways are significant mechanisms in inflammatory responses. It is reported that increased phosphorylation and activation of ERK, JNK, and p38 in AD mice and keratinocytes are a result of the inflammatory response in AD [29,30]. This study showed that the DfE-induced phosphorylation of ERK, JNK, and p38 was decreased by NHGR treatment.…”

Section: Discussionmentioning

confidence: 48%

Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality

et al. 2020

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Atopic dermatitis is a persistent inflammatory skin disorder. Siraitia grosvenorii fruits (monk fruit or nahangwa in Korean, NHG) are used as a natural sweetener and as a traditional medicine for the treatment of asthma and bronchitis. We evaluated the activity of S. grosvenorii residual extract (NHGR) on allergic inflammation of atopic dermatitis in a Dermatophagoides farinae mite antigen extract (DfE)-treated NC/Nga murine model and in vitro. Oral administration of NHGR significantly reduced epidermal hyperplasia and inflammatory cell infiltration in the skin lesions of DfE-induced atopic dermatitis, as well as the dermatitis severity score. NHGR reduced serum immunoglobulin E levels. Splenic concentrations of IFN-γ, interleukin (IL)-4, IL-5, and IL-13 were reduced by NHGR administration. Immunohistofluorescence staining showed that NHGR administration increased the protein levels of claudin-1, SIRT1, and filaggrin in atopic dermatitis skin lesions. In addition, NHGR inhibited the phosphorylation of mitogen-activated protein kinases and decreased filaggrin and chemokine protein expression in TNF-α/IFN-γ-induced human keratinocytes. Moreover, NHGR also inhibited histamine in mast cells. The quantitative analysis of NHGR revealed the presence of grosvenorine, kaempferitrin, and mogrosides. These results demonstrate that NHGR may be an efficient therapeutic agent for the treatment of atopic dermatitis.

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“…Filaggrin expression decreased by TNF-α and IFN-γ is related to activation of JNK, and CS stimulation increased filaggrin expression by blocking activation of JNK in contrast to other reports ( Figs. 1 and 4) [25,26]. These results indicate that JNK is a key molecule that controls filaggrin expression.…”

Section: Discussionmentioning

confidence: 68%

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

Cha¹,

Song²,

Lee³

et al. 2019

Int. J. Med. Sci.

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Chaenomeles sinensis Koehne (CS) has been used in a traditional oriental medicine for treating throat diseases, anaphylaxis, viral infection, and inflammation. This study investigated the underlying mechanism of anti-allergic effect of CS. Leaves of CS plants were dried, powdered, and then underwent extraction with DMSO. Both ELISA and western blotting were performed to evaluate cytokine concentration and the expression and activation of filaggrin and JNK. Five-week-old female NC/Nga mice were used as an AD-like mouse model by treating them with 2,4-dinitrochlorobenzene (DNCB). The secretion of TARC, MCP-1, and IL-8 is increased by TNF-α and IFN-γ in HaCaT cells, and CS extract inhibited the increased production of TARC, MCP-1, and IL-8. TNF-α and IFN-γ suppressed filaggrin expression by activating JNK. CS extract recovered the expression of filaggrin decreased by TNF-α and IFN-γ by blocking the activation of JNK. In vivo experiment, CS administration reduced thickening of the epidermis and infiltration of inflammatory cells into the dermis as compared to DNCB treatment. Moreover, the decrease of filaggrin expression due to DNCB treatment was recovered by CS administration. The serum IgE level was decreased by CS treatment. The levels of IL-4, IL-5, IL-13 and eotaxin in mouse splenocytes increased after treatment with concanavalin A, and the secretions of IL-4, IL-5, IL-13 and eotaxin were lower in the CS-treated group than in the DNCB group. These results may contribute to the development of a CS-based drug for the treatment of atopic dermatitis.

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Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo

Cited by 22 publications

References 42 publications

Effectiveness and Safety of Panax ginseng Extract on Hepatic Dysfunction: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Effectiveness and Safety of Panax ginseng Extract on Hepatic Dysfunction: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Siraitia grosvenorii Residual Extract Attenuates Atopic Dermatitis by Regulating Immune Dysfunction and Skin Barrier Abnormality

Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice

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