Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Luo, Hong-Yang; Zhu, Jieying; Chen, Min; Mu, Wang-Jing; Guo, Liang

doi:10.1016/j.gendis.2022.06.005

Cited by 13 publications

(8 citation statements)

References 77 publications

(175 reference statements)

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“…White adipocytes are important for energy homeostasis, as it is able to metabolize glucose as well as to store and release energy-rich fatty acids. 48 , 49 Beige adipocytes and brown adipocytes are enriched in mitochondria that allow energy dissipation as heat. 50 , 51 Nrg4 is expressed mainly in adipose tissue, especially in BAT, 2 and several studies have shown that Nrg4 expression is increased significantly in WAT and to a lesser extent in BAT after cold exposure.…”

Section: Physiological Roles Of Nrg4mentioning

confidence: 99%

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Chen¹,

Zhu²,

Luo³

et al. 2024

Genes & Diseases

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Section: Physiological Roles Of Nrg4mentioning

confidence: 99%

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Chen¹,

Zhu²,

Luo³

et al. 2024

Genes & Diseases

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“…In a Streptozocin (STZ)-induced hyperglycemic zebrafish model, Wang et al ( 61 ) found that decreasing phosphorylated AMPK elevated p53, leading to KLF2a downregulation, which in turn, promoted cardiomyocyte apoptosis and induced cardiac remodeling and dysfunction. KLF10 participates in the regulation of various aspects of tissue homeostasis and cellular functions, including proliferation, differentiation, and apoptosis ( 155 , 156 ). In a study by Kong et al ( 157 ), loss-of-function analyses of the zebrafish homologs of human KLF10 were conducted using antisense morpholino (MO).…”

Section: Klfs and Cardiomyopathymentioning

confidence: 99%

Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities

Gui,

Liu,

Jin

et al. 2024

Front. Cardiovasc. Med.

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Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy. Herein, we reviewed seven of the most common types of cardiomyopathies, including Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), diabetic cardiomyopathy, Dilated Cardiomyopathy (DCM), desmin-associated cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), Ischemic Cardiomyopathy (ICM), and obesity cardiomyopathy, focusing on their definitions, epidemiology, and influencing factors. Cardiomyopathies manifest in various ways ranging from microscopic alterations in cardiomyocytes, to tissue hypoperfusion, cardiac failure, and arrhythmias caused by electrical conduction abnormalities. As pleiotropic Transcription Factors (TFs), the Krüppel-Like Factors (KLFs), a family of zinc finger proteins, are involved in regulating the setting and development of cardiomyopathies, and play critical roles in associated biological processes, including Oxidative Stress (OS), inflammatory reactions, myocardial hypertrophy and fibrosis, and cellular autophagy and apoptosis, particularly in diabetic cardiomyopathy. However, research into KLFs in cardiomyopathy is still in its early stages, and the pathophysiologic mechanisms of some KLF members in various types of cardiomyopathies remain unclear. This article reviews the roles and recent research advances in KLFs, specifically those targeting and regulating several cardiomyopathy-associated processes.

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“…Sci. 2024, 25, x FOR PEER REVIEW 3 of 17 duced by TGF-β and is implicated in various biological processes such as cell proliferation, differentiation, apoptosis, and immune responses [20]. The role of KLF10 in fibrosis has gained attention, particularly its interaction with pivotal signaling pathways, including TGF-β/SMAD3, ER stress, and metabolic reprogramming [18,21].…”

Section: Klf10 Gene Structure and Variationsmentioning

confidence: 99%

“…In recent years, Krüppel-like factor 10 (KLF10), initially designated as TGF-β-inducible early gene-1 (TIEG1), has emerged as a critical player in fibrosis [17][18][19]. As a member of the KLF family of zinc-finger transcription factors, KLF10 is significantly induced by TGF-β and is implicated in various biological processes such as cell proliferation, differentiation, apoptosis, and immune responses [20]. The role of KLF10 in fibrosis has gained attention, particularly its interaction with pivotal signaling pathways, including TGF-β/SMAD3, ER stress, and metabolic reprogramming [18,21].…”

Section: Introductionmentioning

confidence: 99%

New Insights into the Role of KLF10 in Tissue Fibrosis

Yaseen,

Hwang,

Park

et al. 2024

IJMS

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Fibrosis, characterized by excessive extracellular matrix accumulation, disrupts normal tissue architecture, causes organ dysfunction, and contributes to numerous chronic diseases. This review focuses on Krüppel-like factor 10 (KLF10), a transcription factor significantly induced by transforming growth factor-β (TGF-β), and its role in fibrosis pathogenesis and progression across various tissues. KLF10, initially identified as TGF-β-inducible early gene-1 (TIEG1), is involved in key biological processes including cell proliferation, differentiation, apoptosis, and immune responses. Our analysis investigated KLF10 gene and protein structures, interaction partners, and context-dependent functions in fibrotic diseases. This review highlights recent findings that underscore KLF10 interaction with pivotal signaling pathways, such as TGF-β, and the modulation of gene expression in fibrotic tissues. We examined the dual role of KLF10 in promoting and inhibiting fibrosis depending on tissue type and fibrotic context. This review also discusses the therapeutic potential of targeting KLF10 in fibrotic diseases, based on its regulatory role in key pathogenic mechanisms. By consolidating current research, this review aims to enhance the understanding of the multifaceted role of KLF10 in fibrosis and stimulate further research into its potential as a therapeutic target in combating fibrotic diseases.

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Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes

Cited by 13 publications

References 77 publications

The journey towards physiology and pathology: Tracing the path of neuregulin 4

The journey towards physiology and pathology: Tracing the path of neuregulin 4

Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities

New Insights into the Role of KLF10 in Tissue Fibrosis

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