2015
DOI: 10.1002/mc.22277
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Krüppel‐like factor 9 was down‐regulated in esophageal squamous cell carcinoma and negatively regulated beta‐catenin/TCF signaling

Abstract: Krüppel-like factor 9 (KLF9) has been found to play suppressive roles in several types of tumor. However, the expression pattern and biological functions of KLF9 in esophageal squamous cell carcinoma (ESCC) are still unknown. In this study, it was found that the expression of KLF9 was significantly down-regulated in ESCC compared to their adjacent normal esophageal tissues. Meanwhile, the expression of KLF9 was inversely correlated with the clinical features of ESCC patients. Moreover, in the biological functi… Show more

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Cited by 23 publications
(22 citation statements)
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“…KLF4 interacts with beta-catenin in the progression of colon cancer and regulates tumor growth and differentiation [21,22]. Similarly, KLF9 has been found to interact with betacatenin in the ESCC cell lines [20]. Combining with the present study, the regulation of beta-catenin/TCF signaling might be a common feature shared by the most of KLF proteins.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…KLF4 interacts with beta-catenin in the progression of colon cancer and regulates tumor growth and differentiation [21,22]. Similarly, KLF9 has been found to interact with betacatenin in the ESCC cell lines [20]. Combining with the present study, the regulation of beta-catenin/TCF signaling might be a common feature shared by the most of KLF proteins.…”
Section: Discussionsupporting
confidence: 77%
“…Emerging evidence has pointed to the function of KLF family proteins in the tumorigenesis, such as gastric cancer, colon cancer, esophageal squamous cell carcinoma (ESCC), and lung cancer [12,15,19,20]. However, the expression and biological functions of KLF proteins in the progression of pancreatic cancer remain poorly understood.…”
Section: Discussionmentioning
confidence: 99%
“…For example, in esophageal squamous cell carcinoma, KLF9 was known to inhibit tumor growth and metastasis through negatively regulating Wingless/ integrated (Wnt)/b-catenin signaling. KLF9 could also suppress breast cancer invasion by inhibiting MMP9 transcription (45). In addition, KLF9 positively regulates p53 in hepatocellular carcinoma cells, which further induces cell apoptosis (13).…”
Section: Discussionmentioning
confidence: 99%
“…1B). In this study, we focused on KLF9, a member of the Krüppel-like factor family (10)(11)(12)(13)45). The function of KLF9 in GC metastasis remains unknown.…”
Section: Identification Of Klf9 As a Metastasisassociated Tf Of Gcmentioning
confidence: 99%
“…We chose to fix our eyes on EIF3i and previous study has showed that EIF3i promote the colon oncogenesis through β-catenin activation [11]. On the other hand, β-catenin signaling pathway has been presented as a classic pathway for the progression of different malignant tumors, including ESCC [10, 19]. Therefore, we assumed that EIF3B might act in the similar way and performed the corresponding assays.…”
Section: Discussionmentioning
confidence: 99%