Kv1.3 Current Voltage Dependence in Lymphocytes is Modulated by Co-Culture with Bone Marrow-Derived Stromal Cells: B and T Cells Respond Differentially

Abstract

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Potassium channels: Novel targets for tumor diagnosis and chemoresistance

“…Combined with AraC caused ALL cell proliferation arrest and cell death by increasing CytC release as well as promoting caspase-9 and caspase-3 activation ( 55 ). Kv1.3 channels are the only voltage-dependent potassium channels in the plasma membrane of human lymphocytes ( 69 ).Compared with healthy lymphocytes, Kv1.3 is highly expressed in the plasma membrane and mitochondria of human CLL cells. The mitogenic agent PAPTP, which specifically targets this channel, effectively kills pathological B cells in the spleen and peritoneal cavity.…”

Reduction of Ca2+ Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells

“…There are two K + -selective channels in human lymphocytes, already mentioned KCa3.1 and voltage-dependent Kv1.3 channel. Kv1.3 channel dominates in resting B and T lymphocytes and can potentially support CRAC, albeit it has a limited repolarization capacity, as these channels are closed completely at voltages below −60 mV [ 22 ]. In activated T and B cells, where the KCa3.1 channel is strongly upregulated, the function of the latter becomes pivotal, and the role of Kv1.3 diminishes [ 23 ].…”