Kyrle's disease

Cunningham, Sandra; Walsh, Maureen; Matthews, Robert; Fulton, R. A.; Burrows, D.

doi:10.1016/s0190-9622(87)70011-5

Cited by 29 publications

(11 citation statements)

References 9 publications

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“…Very rarely a familial predisposition has been reported supporting the view that this represents a genodermatosis with an autosomal recessive trait 12–14. The disease could also present in adulthood, more commonly in women between 30 and 50 years of age 1214…”

Section: Discussionmentioning

confidence: 93%

Rare presentation of Kyrle′s disease in siblings

et al. 2008

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Background:Kyrle's disease is a rare variant of primary perforating dermatosis. Its occurrence in a familial setting, especially in children, is extremely uncommon. Similar appearing skin lesions have been described in adults, secondary to metabolic disorders, infective agents as well as exposure to chemicals. We present a rare case of this genodermatosis in two siblings.Materials and Methods:Two siblings of a non-consanguineous marriage came with generalized discrete papular lesions with a central keratotic plug. All biochemical and serological investigations were within normal limits. Serial sections of the biopsy revealed typical epidermal invaginations filled with parakeratotic debris and perforation into the dermis with accompanying granulomatous reaction.Results and Conclusions:A careful history, detailed routine investigations and serial sections of the skin biopsy are required to demonstrate the typical morphology and stages of evolution of Kyrle's disease. This helps to differentiate the rare primary Kyrle's disease from other primary and secondary keratotic lesions. Due to the familial occurrence, screening of relatives of an index case is recommended.

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Section: Discussionmentioning

confidence: 93%

Rare presentation of Kyrle′s disease in siblings

et al. 2008

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“…4 It predominately affects females with a 6:1 ratio compared to males. 5 It is a hereditary skin disease (genodermatosis), although the mode of inheritance remains controversial. It is reported to the literature that Kyrle's disease was found in a family of three generations, suggesting an autosomal dominant mode of heredity.…”

Section: Discussionmentioning

confidence: 99%

Regression of skin lesions of Kyrle's disease with clindamycin: implications for an infectious component in the etiology of the disease

Kasiakou

Peppas

Kapaskelis

et al. 2005

Journal of Infection

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“…In the fully evolved lesions, additional histologic features may be seen. The keratin plug may penetrate the epidermis at the site where granular layer is absent and induce a granulomatous response in the dermis (62,63). This granuloma is eliminated through the plug as basophilic debris devoid of elastic tissue (60).…”

Section: Kyrle's Disease (Kd)mentioning

confidence: 99%

“…The lesions resolve following treatment, but may recur after discontinuation of the therapy. The beneficial effect of retinoids is attributed to increased proliferation of the epidermis with faster elimination of necrotic dermal material (6) and also to correction of an intrinsic keratinization defect (63). Retinoids also diminish fibroblast proliferation and collagen synthesis (115).…”

Section: Elastosis Perforans Serpiginosamentioning

confidence: 99%

“…The abnormally rapid keratinization results in a hyperparakeratotic column that may disrupt the epidermis to perforate into the dermis, eliciting a granulomatous responses. However, the abnormality of epidermal keratinization in Kyrle's disease has been doubted by Cunningham et al (63) who demonstrated normal keratin bands on sodium dodecylsulfate gel electrophoresis.…”

Section: Pathogenesismentioning

confidence: 99%

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Perforating Dermatoses: A Review and Report of Four Cases

Sehgal¹,

Jain²,

Thappa³

et al. 1993

The Journal of Dermatology

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Perforating dermatoses, an often overlooked entity comprised of Kyrle's disease, perforating folliculitis, reactive perforating collagenosis, elastosis perforans serpiginosa, and acquired perforating dermatosis, are succinctly described, focusing attention on their clinical features, histopathology, treatment, and pathogenesis. The literature on these facets has been extensively reviewed. In addition, three fresh cases of Kyrle's and one of perforating folliculitis have been incorporated to illustrate these conditions.

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Kyrle's disease

Cited by 29 publications

References 9 publications

Rare presentation of Kyrle′s disease in siblings

Rare presentation of Kyrle′s disease in siblings

Regression of skin lesions of Kyrle's disease with clindamycin: implications for an infectious component in the etiology of the disease

Perforating Dermatoses: A Review and Report of Four Cases

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