L‐arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Nasr El-Din, Wael Amin; Abdel Fattah, Islam Omar

doi:10.1016/j.tice.2024.102572

Tissue and Cell

2024

DOI: 10.1016/j.tice.2024.102572

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L‐arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Wael Amin Nasr El-Din,

Islam Omar Abdel Fattah

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Arginine Maillard Reaction Products Recovered Damaged Immune Cells

Ding,

Rao,

Zhou

et al. 2024

Preprint

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Instant noodle has been an initiating point for food industry in many countries, and it continues to be a beloved convenient food in the world. However, some products cause discomfort after consumption despite full compliance in both ingredients and processing methods. It has not only resulted in serious consumer misunderstanding but also affect the industry as well. A simple solution possibly lies in nowhere but its soup which uses Maillard reaction products as flavoring agents. Arginine-glucose MRPs (Arg-Glc MRPs) have been demonstrated to be antioxidant and anti-inflammatory, which can be useful to remove food caused discomfort. Here we show that Arg-Glc MRPs neither produced significant cytotoxicity nor caused oxidative stress in RAW264.7 macrophages. In APPH-induced oxidative damage model they remarkably reduced cytoplasmic ROS and O2·−, and restored the polarization of cytoplasmic membrane potential and mitochondrial membrane potential while enhancing the phagocytic function of normal cells and oxidatively damaged cells. Those in vitro results indicate that usage of Arg-Glc MRPs in the soup can be a promising solution to discomfort problems.

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Arginine Maillard Reaction Products Recovered Damaged Immune Cells

Ding,

Rao,

Zhou

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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L‐arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Cited by 1 publication

References 72 publications

Arginine Maillard Reaction Products Recovered Damaged Immune Cells

Arginine Maillard Reaction Products Recovered Damaged Immune Cells

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