L‐Dopa Effect on Prolactin Plasma Levels in Complicated and Common Migrainous Patients

Vardi, J.; Flechter, Shlomo; Ayalon, D.; Cordova, T.; Oberman, Z

doi:10.1111/j.1526-4610.1981.hed2101014.x

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…He noted high plasma levels of PRL during attacks and suggested that the reduction by the use of specific drugs might be a useful approach to treat these attacks. The release of PRL is inhibited by GABA at the anterior pituitary level (13)(14)(15)(16)(17)(18)(19)(20)(21)(22); sodium valproate may therefore inhibit PRL release and thus influence the migraine attack.…”

Section: Discussionmentioning

confidence: 99%

Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo

1992

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The efficacy of sodium valproate (Depalept) versus placebo in the treatment of migraine was evaluated in a double-blind randomized cross-over study in twenty-nine patients. The patients were divided into two groups each of which was alternately given 400 mg of sodium valproate B.I.d or placebo for eight weeks and then crossed over for an additional eight weeks. Our results show that in 86.2% of the patients sodium valproate was effective in preventing migraine or reducing the frequency, severity and duration of the attacks. In general, the drug was well tolerated and proved to be an effective treatment in migraine.

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Section: Discussionmentioning

confidence: 99%

Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo

1992

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“…4 Also, several studies have been performed by means of dynamic tests of PRL secretion, by many workers. [5][6][7][8][9][10][11] These researches were carried on also after differential treatment periods, either using bromocriptine or 5-OH-tryptophan, methysergide or lisuride. 6,9 However, the results of all these studies did not reach agreement on the possible relationship between prolactin levels and migraine.…”

Section: Introductionmentioning

confidence: 99%

Prolactin and Migraine: Effect of L‐Dopa on Plasma Prolactin Levels in Migraineurs and Normals

et al. 1986

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SYNOPSIS Since in migraineurs a change in dopaminergic tone has been hypothesized and since in man prolactin secretionby the lactotroph cells is controlled by hypothalamic inhibitory factors (of which dopamine is the best known), wedecided to investigate plasma prolactin (PRL) response to L‐Dopa in a group of migraineurs.We tested 5 women suffering from common migraine and 5 healthy women as controls.A different behaviour of PRL secretion was observed in the two groups. In migraineurs the inhibition of PRLsecretion was less marked than in normals, with a statistically significant difference at 30 and 60 minutes.This difference might suggest a reduced responsiveness of the pituitary lactotroph cells to the action ofdopaminergic agents. The mechanisms accounting for this peculiar behaviour of PRL secretion in migraineurs arestill to be elucidated.

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“…[7][8][9] In the present study, we investigated the PRL response to thyrotropin-releasing-hormone (TRH) in female patients suffering from migraine, in the intervals between attacks and during an attack.…”

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confidence: 99%

Increased prolactin response to thyrotropin releasing hormone during migraine attacks.

Papakostas¹,

Daras²,

Markianos³

et al. 1987

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Prolactin (PRL) has been associated with the pathogenesis of migraine, and various approaches have been used to investigate its role. In the present study, the PRL response to thyrotropin-releasing hormone (TRH) was evaluated in eight women migraineurs during an attackfree state and during a migraine attack. PRL baseline values were not different in the two states, and the same was true for the TSH responses to TRH. The PRL responses to TRH were, however, significantly higher during the attack, a finding that indicates a latent disturbance of the PRLregulating systems in migraine, with a higher responsiveness during migraine attacks.Increased levels of plasma prolactin (PRL) found in some conditions associated with migraine attacks (stress, exercise, use of oral contraceptives), and the PRL suppressing effect of some anti-migraine drugs (ergot alkaloids, clonidine), are observations that support the notion that PRL is involved in the mechanism of migraine pathogenesis.1 2 Certain studies, however, failed to demonstrate a PRL involvement,3`6 while others, using the levodopa inhibiting test, showed some abnormalities in the PRL secretion mechanisms in migraine.7-9 In the present study, we investigated the PRL response to thyrotropin-releasing-hormone (TRH) injury within the last year or evidence of endocrine abnormalities were excluded. All patients were free of drugs during the 2 weeks before testing, and were found normal in a systematic physical and neurological examination. Their EEGs and CTs of the head were also normal. They all had a formal psychiatric examination, and the Hamilton Depression Scale'" was completed. No evidence of depression or other significant psychiatric disturbance was found.The first TRH test was performed during an attack free interval. The patient was then instructed to come during an attack to have the test repeated, if the attack occurred during the morning hours. The TRH test was thus always performed between 0800 and 1200 hours, with the patient recumbent. Blood samples were drawn throtigh an indwelling catheter that was kept patent with slow infusion of normal saline. After the first blood sample was obtained (time 0) 0 4 mg TRH were given IV as a bolus and samples were further obtained at 20, 40 and 60 minutes. Plasma was separated by centrifugation and kept at -30°C until estimation. PRL levels were assayed by radioimmunoassay techniques (Biodata kit) and the results expressed in ng/ml.

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L‐Dopa Effect on Prolactin Plasma Levels in Complicated and Common Migrainous Patients

Cited by 5 publications

References 25 publications

Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo

Sodium Valproate in The Prophylactic Treatment of Migraine: A Double-Blind Study Versus Placebo

Prolactin and Migraine: Effect of L‐Dopa on Plasma Prolactin Levels in Migraineurs and Normals

Increased prolactin response to thyrotropin releasing hormone during migraine attacks.

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