l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

Kim, Tae Il; Lee, Yong Kyung; Park, Sang Gi; Choi, Im Seop; Ban, Jung Ok; Park, Hyoung Kook; Nam, Sang-Yoon; Yun, Young Won; Han, Sang Bae; Oh, Ki Wan; Hong, Jin Tae

doi:10.1016/j.freeradbiomed.2009.09.008

Cited by 183 publications

(105 citation statements)

References 60 publications

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“…These preventive effects of thiacremonone on oxidative damages of APP/PS1 mice brain are in agreement with previous findings showing that thiacremonone effectively inhibited lipopolysaccharide (LPS)-induced inflammatory mediator as well as amyloidogenesis through blocking of ROS and oxidative stress [19]. It was also reported that 4-O-methylhonokiol prevents amyloidogenic and memory-improving effect via antioxidant mechanism in mutant presenilin 2 (PS2) and Swedish APP AD mice brains [18,30]. Moreover, these preventive effects on oxidative stress are paralleled with inhibition of BACE1 expression and β-secretase activity as well as Aβ deposition.…”

Section: Discussionsupporting

confidence: 92%

“…Activation of NF-κB and MAPK pathways is critical related to the proteolytic processing of APP as well as to Aβ-induced secretase activity, oxidative stress, and neuronal cell death [14]. We also reported the significance of MAPK and NF-κB activities in Aβ-induced neuronal cell death [15] and also the inhibition of the MAPK and NF-κB pathways by green tea extract and prevention of Aβ-induced neuronal cell death by 4-Omethylhonokiol [16][17][18].…”

Section: Introductionmentioning

confidence: 66%

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Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

et al. 2015

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Alzheimer's disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) peptide. Evidence suggests that amyloid accumulation can be caused by oxidative stress and inflammatory responses. In this study, we examined neuroprotective effects of thiacremonone, an anti-oxidant and anti-inflammatory compound isolated from garlic. Treatment of thiacremonone significantly attenuated cognitive impairments in amyloid precursor protein (APP)/presenilin 1 (PS1) double-mutant transgenic mice. In addition, activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and extracellular signal-regulated kinase (ERK) pathways in the brain was potently inhibited by thiacremonone. We also observed that thiacremonone significantly inhibited activation of NF-κB and ERK pathways induced by H2O2 and Aβ1-42 in embryonic neuronal cells. Furthermore, thiacremonone augmented peroxiredoxin 6 (PRDX6) expression in vivo and in vitro associated with reduced oxidative stress of macromolecules such as protein and lipids. This study indicates that thiacremonone might exert memory improvement via stimulating anti-oxidant system. These multiple properties could attenuate Aβ accumulation and oxidative stress in Alzheimer's brains. Thus, these results suggest that thiacremonone might be useful to intervene development or progression of neurodegeneration in AD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 66%

Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

et al. 2015

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“…Similar results were observed that activation ERK and JNK mediated a caspase-dependent pathway in cadmium induced PC12 cells and primary rat cerebral cortical neurons apoptosis [15,46]. L-Theanine suppresses ERK/ p38 kinase and NF-jB pathways to attenuate Ab-induced cognitive dysfunction and neurotoxicity [47]. In our study, PC12 cells pretreatment L-theanine significantly inhibited cadmium induced the activation of ERK and JNK pathways, but not p38.…”

Section: Discussionsupporting

confidence: 89%

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

et al. 2015

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L-Theanine is an amino acid derivative from green tea. The present work was aimed at the effect of L-theanine on neuron-like rat pheochromocytoma (PC12) cells stimulated with cadmium chloride. Treatment with L-theanine before cadmium exposure increased cell viability; the experiments of Annexin V/PI staining indicated that L-theanine inhibited cadmium-induced cell apoptosis. Meanwhile, L-theanine decreased ROS production and protected from cadmium-induced disruption of mitochondrial transmembrane potential. Compared with cadmium-treated cells, L-theanine could also decrease the ratio of Bax/Bcl-2, as well as the level of cleaved caspase-9, caspase-3 and poly(ADP-ribose) polymerase. Furthermore, L-theanine depresses cadmium-induced up regulation of phosphorylations of PI3K/Akt, MAPK ERK1/2, and JNK signaling. These data suggest that L-theanine pretreatment reduces severity of cadmium toxicity probably via antioxidant action. Therefore, it may be concluded that L-theanine could be exploited for prevention of cadmium-induced diseases.

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“…Because suppression of NF-jB activation has been linked with anti-inflammation, we postulated that theanine mediates its effects at least partly through suppression of NF-jB activation. A recent study reported that theanine inhibited neuronal cell death via an inhibition of b-amyloid induced NF-jB activation pathways (Kim et al 2009). In this study, we also observed that theanine suppresses NF-jB activation induced by PMACI.…”

Section: Discussionmentioning

confidence: 99%

Theanine is a candidate amino acid for pharmacological stabilization of mast cells

2011

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The increasing occurrences of allergic disorders may be attributed to exposure to environmental factors that contribute to the pathogenesis of allergy. The health benefits of green tea have been widely reported but are largely unsubstantiated. Theanine is the major amino acid present in green tea. In this study, we investigated the role of theanine in both IgE- and non- IgE-induced allergic response. Theanine inhibited compound 48/80-induced systemic anaphylactic shock and ear swelling responses. IgE-mediated passive cutaneous anaphylaxis was inhibited by the oral administration or pharmaceutical acupuncture of theanine. Histamine release from mast cells was decreased with the treatment of theanine. Theanine also repressed phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced TNF-α, IL-1β, IL-6, and IL-8 secretion by suppressing NF-κB activation. Furthermore, theanine suppressed the activation of caspase-1 and the expression of receptor interacting protein-2. The current study demonstrates for the first time that theanine might possess mast cell-stabilizing capabilities.

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l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

Cited by 183 publications

References 60 publications

Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway

Theanine is a candidate amino acid for pharmacological stabilization of mast cells

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