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Abstract

Uncontrolled diabetes is a major cause of blindness, kidney failure, heart attacks, stroke, and lower limb amputation. In 2019, diabetes was the ninth leading cause of death, with an estimated 1.5 million deaths directly caused by diabetes 1 . Sulphonylureas are a medicine used to enhance insulin release to control sugar levels in the normal range.Glibenclamide (Glb) is one of the most potent second-generation sulphonyurea (dose 2.5-20 mg) for it. Glb is highly lipophiic (pka-5.3) and BCS class II drug. This drug shows variable oral bioavailability due to poor drug solubility and dissolution. It also shows serious and sometimes fatal side effects like hypoglycemia attack and