La carga de la enfermedad por rotavirus en niños menores de cinco años, Colombia, 2004

Abstract

Rotavirus infection is an important cause of morbidity and mortality from diarrhea, particularly during the first years of life, when children are more susceptible to serious complications. It is important for prevention strategies to have a high impact before 6 months of age, and vaccination against rotavirus can be a good complementary intervention strategy. No description was found in the international scientific literature of the seasonal variations in rotavirus genotypes. It is important to carry out cost-effectiveness studies in order to promote the investment of resources in accordance with population needs, and to continue surveillance activities so as to better understand how the virus behaves.

Viral gastroenteritis and diversity of rotavirus strains in Colombian children: a systematic review

“…Detection rates of RVA, RVC, CV, AstV and AdV from 23 studies reviewed are listed in Table 2 [7,8,25]. Overall, RVA was the most prevalent pathogen detected in a median of 35.5% of the children.…”

“…Andean/Central region: In Bogotá, RVA was detected in a median of 32.0 % of children [7,11,13,[15][16][17]19], and AdV 40/41 in a median of 9.6% [13,16]. In Facacativá near Bogotá, the detection rate of RVC was 20.2%; RVA, AdV 4041 and AstV were detected in a median of 15.5%, 1.8% and 2.6% of children.…”

“…We included studies in Spanish and English published from 1984 to 2006 [7,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25], which have fulfilled the following requirements: b) The study used standardized laboratory techniques for identification and typing of viral agents. All methods considered included the enzyme-linked immunosorbent assay (ELISA), polyacrylamide gel electrophoresis (PAGE), latex agglutination (LA), and the reverse transcription polymerase chain reaction (RT-PCR)…”

“…We also considered the two studies on RVA genotypes up to now, (published between 2004 and 2006) which examined > 50 rotavirus samples and tested them for both G and P types by means of RT-PCR [7,26]. The results of these studies were tabulated to examine the frequency of individual G and P rotavirus genotypes, as well as G-P common (G1P [8], G2P [4] G3P [8]) and G4 [8]) and the remaining uncommon strains.…”

“…Each year, RVA causes approximately 111 million episodes of gastroenteritis requiring only home care, 25 million clinic visits, 2 million hospitalizations, and 352,000-592,000 deaths (median, 440,000 deaths) in children under five years of age [6]. A report in Colombia estimated that RVA caused 1 death/ 2.000 children, 16 hospitalizations and 631 clinic visits per each 1,000 children in 2004 [7].…”