La déclaration RECORD-PE (Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepdemiology) : directives pour la communication des études realisées à partir de données de santé observationelles collectées en routine en pharmacoépidémiologie

Langan, Sinéad; Schmidt, Sigrún Alba Jóhannesdóttir; Wing, Kevin; Ehrenstein, Véra; Nicholls, Stuart G.; Filion, Kristian B.; Klungel, Olaf H.; Petersen, Irene; Sørensen, Henrik Toft; Dixon, William G; Guttmann, Astrid; Harron, Katie; Hemkens, Lars G; Moher, David; Schneeweiß, Sebastian; Smeeth, Liam; Sturkenboom, Miriam; Elm, Erik von; Wang, Shirley; Benchimol, Eric I

doi:10.1503/cmaj.190347

Cited by 4 publications

(2 citation statements)

References 80 publications

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“…We linked the Med-Echo and RAMQ medical and public drug plan databases through encrypted provincial health insurance numbers. Combining the information from Med-Echo databases, RAMQ medical services, and RAMQ drug plan databases, we obtained a complete history of hospital mortality and hospital admissions, medical services, and drug use of patients in Quebec ( Table S10 ) [ 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Methodsmentioning

confidence: 99%

Antipsychotics and Risks of Cardiovascular and Cerebrovascular Diseases and Mortality in Dwelling Community Older Adults

Perreault,

Boivin Proulx,

Brouillette

et al. 2024

Pharmaceuticals

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This study aims to investigate the effect of antipsychotic agents on cardiovascular and cerebrovascular diseases (CVD/CEV) and mortality risks in the older population living in a community. A cohort of 42,650 new users of antipsychotic agents was built using Quebec healthcare databases (1998–2011). The outcomes were CVD/CEV and mortality incidence in 5 years of follow-up in the total cohort, sub-cohort of patients with no schizophrenia/dementia, sub-cohort with schizophrenia, and sub-cohort with dementia. Comparisons were made between the new users who continued the treatment (adherent level ≥ 60%) vs. those ceasing treatment (adherence level < 60%) using inverse probability of treatment weighting and Cox models. Comparing high adherence vs. low levels, CVD/CEV risk was increased by 36% in the sub-cohort with schizophrenia for atypical antipsychotic users and by 25% in the sub-cohort with dementia for typical antipsychotic users. An increasing mortality risk of 2- to 3-fold was linked with the typical antipsychotic use in all cohorts except the sub-cohort with schizophrenia; in addition, mortality risk is linked with the use of high vs. low doses. Antipsychotics were not linked with CVD/CEV risk, except for atypical antipsychotics in patients with schizophrenia and typical antipsychotics in patients with dementia. The mortality risk was linked with the use of typical antipsychotics and the dose used.

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Section: Methodsmentioning

confidence: 99%

Antipsychotics and Risks of Cardiovascular and Cerebrovascular Diseases and Mortality in Dwelling Community Older Adults

Perreault,

Boivin Proulx,

Brouillette

et al. 2024

Pharmaceuticals

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show abstract

“…Population-based cohorts were built [21][22][23][24] using the Med-Echo administrative databases (hospital discharge reports), the Régie de l'assurance maladie du Québec (RAMQ) medical services, and RAMQ public drug plans all databases administered by the RAMQ [25,26]. The databases were linked via encrypted health insurance numbers.…”

Section: Data Source and Ethics Declarationsmentioning

confidence: 99%

Association between Cardiovascular Diseases and Dementia among various age groups: A Population-Based Cohort Study in Older Adults

Boivin‐Proulx

Brouillette

Dorais³

et al. 2023

Preprint

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The link between cardiovascular (CV) risk factors or diseases and dementia is documented. There is conflicting evidence whether age moderates the association. We need to study this gap so that research and clinical initiatives target appropriate age groups. A cohort of 320,630 adult patients without dementia was built using Quebec healthcare databases (1998–2010). The CV risk factors were hypertension, diabetes and dyslipidemia, while diseases included stroke, myocardial infarction (MI), chronic heart failure (HF), and atrial fibrillation (AF). Dementia risk and CV risk factors or diseases were assessed using incidence rate ratios and Cox regression across age groups. The cohort presented by mainly female sex (67.7%) and mean age of 74.1 years. Incident rate of dementia increased with age, ranging from 4.1 to 93.5 per 1,000 person-years. Diabetes, stroke, HF and AF were significantly associated with dementia risk, hazard ratios ranged from 1.08 to 3.54. The strength of association decreased in advanced age for diabetes, stroke and HF. The results suggest that prevention of diabetes, stroke, HF and AF are crucial to mitigate dementia risk. The pathophysiology of dementia in younger and older populations seems to differ, with less impact of CV risk factors in advanced age.

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Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults

Boivin-Proulx,

Brouillette,

Dorais

et al. 2023

Sci Rep

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The link between cardiovascular (CV) risk factors or diseases and dementia is documented. There is conflicting evidence whether age moderates the association. We need to study this gap so that research and clinical initiatives target appropriate age groups. A cohort of 320,630 adult patients without dementia was built using Quebec healthcare databases (1998–2010). The CV risk factors were hypertension, diabetes and dyslipidemia, while diseases included stroke, myocardial infarction (MI), chronic heart failure (HF), and atrial fibrillation (AF). Dementia risk and CV risk factors or diseases were assessed using incidence rate ratios and Cox regression across age groups. The cohort presented by mainly female sex (67.7%) and mean age of 74.1 years. Incident rate of dementia increased with age, ranging from 4.1 to 93.5 per 1000 person-years. Diabetes, stroke, HF and AF were significantly associated with dementia risk, hazard ratios ranged from 1.08 to 3.54. The strength of association decreased in advanced age for diabetes, stroke and HF. The results suggest that prevention of diabetes, stroke, HF and AF are crucial to mitigate dementia risk. The pathophysiology of dementia in younger and older populations seems to differ, with less impact of CV risk factors in advanced age.

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Cited by 4 publications

References 80 publications

Antipsychotics and Risks of Cardiovascular and Cerebrovascular Diseases and Mortality in Dwelling Community Older Adults

Antipsychotics and Risks of Cardiovascular and Cerebrovascular Diseases and Mortality in Dwelling Community Older Adults

Association between Cardiovascular Diseases and Dementia among various age groups: A Population-Based Cohort Study in Older Adults

Association between cardiovascular diseases and dementia among various age groups: a population-based cohort study in older adults

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