“…It is not surprising that uncontrolled hypertension and family history of early onset cardiovascular 'disease are associated with the development of events. A combination of patient non-compliance and TI (which is not the subject of our study) could be the cause of uncontrolled hypertension, as other studies have shown (10,11,21). Similarly, it is a well-known fact that a family history of early onset cardiovascular disease increases individual risk of an ischaemic event (22,23); the most recent European guidelines acknowledge that a family history of early onset cardiovascular disease multiplies the SCORE table risk by 1.7 in women and 2.0 in men (24).…”