La moitié des patients atteints d’hyperparathyroïdies primaires ont un déficit en vitamine D aggravant l’atteinte osseuse

Vélayoudom-Céphise, Fritz-Line; Foucan, Lydia; Soudan, Benoı̂t; Cardot-Bauters, Catherine; Vantyghem, Marie-Christine; d’Herbomez, Michèle; Tison-Muchery, Françoise; Wémeau, Jean-Louis

doi:10.1016/j.lpm.2010.08.005

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…Our series is in line with the literature [5] [10] [19]. In addition, Velayoudom-Cephise et al [19] found an associated vitamin D deficiency of 51% in a French series.…”

Section: Clinical and Biological Datasupporting

confidence: 92%

“…Thus, in the majority of cases, the diagnosis was easy to establish by demonstrating simultaneous elevation of serum calcium and serum PTH. In 10% of patients, PTH was not clearly elevated but was inappropriate for hypercalcaemia [19]. Our series is in line with the literature [5] [10] [19].…”

Section: Clinical and Biological Datasupporting

confidence: 90%

“…In 10% of patients, PTH was not clearly elevated but was inappropriate for hypercalcaemia [19]. Our series is in line with the literature [5] [10] [19]. In addition, Velayoudom-Cephise et al [19] found an associated vitamin D deficiency of 51% in a French series.…”

Section: Clinical and Biological Datasupporting

confidence: 90%

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Primary Hyperparathyroidia at the Abass Ndao Hospital Center: About 29 Cases

Diédhiou,

Ndour,

Dieng

et al. 2023

OJIM

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Introduction: In Senegal, there is very little data on primary hyperparathyroidism despite an overall upward epidemiological trend. The objective was to describe its epidemiological, clinical, therapeutic and evolutionary aspects. Materials and Methods: This was a cross-sectional, descriptive study, conducted over 5 years (from January 01, 2018 to December 31, 2022) at the National Abass Ndao Hospital Center and including all confirmed cases of primary hyperparathyroidism. Results: Twenty-nine patients were included with a female predominance (86.20%) and an average age of 48.10 ± 18.93 years. The discovery of hyperparathyroidism was fortuitous in 79.31% of cases. The main clinical manifestations were osteoarticular (62%) and urinary (34.5%). On average, serum calcium measured was 109.2 ± 7.92 mg/l, corrected serum calcium 111.3 ± 6.25 mg/l, urinary calcium 421.9 ± 96.45 mg/24h and parathormone at 145 ± 159.71 pg/ml. Among the patients, 25 had hypercalcemia (86.2%) and all had 24-hour hypercalciuria. The diagnosis was retained in view of the elevated parathyroid hormone (PTH) values in all patients. Cervical ultrasound objectified a parathyroid adenoma in 27.58% of cases and 12 patients or 46.2% had presented a scintigraphy in favor of a parathyroid adenoma. We found 01 cases of multiple endocrine neoplasia type 2. Bone densitometry performed in 10 patients found osteoporosis in 60% of cases (6 patients) and osteopenia in 40% of cases (4 patients). Surgical treatment was performed in 12 patients (41.4%). The histology of the surgical specimens was in favor of a parathyroid adenoma in all cases. Among the operated patients, the evolution was marked by a cure rate of 100%. Conclusion: The symptomatology of primary hyperparathyroidism remains mainly osteoarticular and urinary. Surgery has proven its effectiveness in our series.

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“…Our series is in line with the literature [5] [10] [19]. In addition, Velayoudom-Cephise et al [19] found an associated vitamin D deficiency of 51% in a French series.…”

Section: Clinical and Biological Datasupporting

confidence: 92%

Section: Clinical and Biological Datasupporting

confidence: 90%

See 1 more Smart Citation

Primary Hyperparathyroidia at the Abass Ndao Hospital Center: About 29 Cases

Diédhiou,

Ndour,

Dieng

et al. 2023

OJIM

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“…Là aussi, on doit considérer l'hyperparathyroïdie primitive comme une précaution d'emploi, et non comme une contreindication. La moitié des patients atteints d'hyperparathyroïdie primaire ont en effet un déficit en vitamine D aggravant l'atteinte osseuse [61]. Une publication rapporte le traitement par vitamine D de 21 cas d'hyperparathyroïdie primitive visant à maintenir le taux de 25-(OH)-vitamine D supérieur à 20 ng/mL.…”

Section: Y A-t-il Un Risque D'hypercalciurie Et De Lithiase Rénale ?unclassified

La vitamine D chez l’adulte : recommandations du GRIO

Benhamou¹,

Souberbielle²,

Cortet³

et al. 2011

La Presse Médicale

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Serum level of 25-(OH)-vitamin D is a reliable marker of vitamin D repletion and therefore medical management can be based on its evaluation at both an individual-and population-based level. In every situation when the therapeutic goal requires an optimal serum 25-(OH)-vitamin D level for an appropriate medical care, it is mandatory to measure baseline level in order to define loading and maintenance dosages of vitamin D supplementation. These situations include lack or very low sun exposure, falls, osteoporosis, diseases or treatments known to induce osteoporosis, chronic pathologies associated with vitamin D insufficiency. On the other hand, supplementation can be a systematic approach with no biological testing in all patients over 65 years old since the risk of low vitamin D levels is quite high while the risk of excessive dose is almost null in this population. Points essentielsLe taux de 25-(OH)-vitamine D circulante est un reflet fidèle de l'imprégnation vitaminique D et constitue un marqueur biologique sur lequel on peut fonder le raisonnement médi-cal, aussi bien dans une population que chez un individu. Dans toutes les situations au cours desquelles l'objectif thérapeutique est d'obtenir un taux optimal de 25-(OH)-vitamine D pour une prise en charge adaptée, il est néces-saire de connaître la valeur sérique initiale pour adapter les schémas d'attaque et d'entretien de la supplémentation. Parmi ces situations on peut inclure tous les sujets ayant une exposition solaire nulle ou quasi nulle, des chutes à répétition, une ostéoporose avérée, une maladie favorisant l'ostéoporose, des médicaments inducteurs d'ostéoporose, une pathologie chronique sévère favorisant l'insuffisance et la carence. En revanche, il nous paraît licite d'envisager une approche préventive de supplémentation systématique, sans dosage chez tous les sujets de 65 ans et plus, dont la probabilité d'un déficit en vitamine D est extrêmement élevée, alors que le risque de surdosage est quasi nul. tome 40 > n87/8 > juillet-août 2011

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High Vitamin D Deficiency Rate in Metabolic Inpatients: Is Bariatric Surgery Planning Found Guilty?

et al. 2014

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No significant difference in 25(OH) vitamin D level could be demonstrated between obese patients before bariatric surgery and obese patients with no obesity surgery project. No difference was found between our Parisian obese population and a Spanish obese population, which benefits from a better solar exposure. Both findings suggest that obesity itself is the link with vitamin D deficiency, independently from behavioral differences.

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La moitié des patients atteints d’hyperparathyroïdies primaires ont un déficit en vitamine D aggravant l’atteinte osseuse

Cited by 10 publications

References 33 publications

Primary Hyperparathyroidia at the Abass Ndao Hospital Center: About 29 Cases

Primary Hyperparathyroidia at the Abass Ndao Hospital Center: About 29 Cases

La vitamine D chez l’adulte : recommandations du GRIO

High Vitamin D Deficiency Rate in Metabolic Inpatients: Is Bariatric Surgery Planning Found Guilty?

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