La pancytopénie : une complication grave de la miliaire tuberculeuse

Achi, H.V.; Ahui, B.J.M.; Anon, J.C.; Kouassi, B.; Dje-Bi, H.; Kininlman, H.

doi:10.1016/j.rmr.2012.08.008

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…Bone marrow suppression and pancytopenia are known complications of chronic infectious diseases including mycobacterial infections(Achi et al, 2013). Since mycobacterial infections frequently co-occur with myelofibrosis, many have assumed that pancytopenia is due to physical disruption of the bone marrow (Viallard et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…These diseases are associated with significant health implications including bone marrow suppression and an increased risk for cancer (Ramos-Casals et al, 2003; Scadden et al, 1989). Pancytopenia, a suppression of blood counts across multiple lineages, can affect as many as 12% of people with disseminated or miliary tuberculosis, and increases risk of death from the infection (Achi et al, 2013). Collectively, these observations suggest that chronic infections may significantly affect the function of hematopoietic stem cells (HSCs), the progenitor cells of all blood cells.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Matatall¹,

et al. 2016

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Summary Chronic infections affect a third of the world’s population and can cause bone marrow suppression, a severe condition that increases mortality from infection. To uncover the basis for infection-associated bone marrow suppression, we conducted repeated infection of WT mice with Mycobacterium avium. After 4–6 months, mice became pancytopenic. Their hematopoietic stem and progenitor cells (HSPCs) were severely depleted and displayed interferon gamma (IFNγ) signaling-dependent defects in self-renewal. There was no evidence of increased HSPC mobilization or apoptosis. However, consistent with known effects of IFNγ, transcriptome analysis pointed towards increased myeloid differentiation of HSPCs and revealed the transcription factor Batf2 as a potential mediator of IFNγ-induced HSPC differentiation. Gain and loss of function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Matatall¹,

et al. 2016

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“…Patients with aplastic anemia, a disease characterized by loss of HSPCs and pancytopenia, have high levels of IFNg in their serum (Nisticò and Young, 1994;Young and Maciejewski, 1997). Similarly, infectious diseases such as hepatitis C and chronic mycobacterial infections that induce IFNg-mediated immune responses are associated with impaired hematopoiesis (Achi et al, 2013;Ramos-Casals et al, 2003;Scadden et al, 1989). However, the exact mechanisms by which IFNg damages hematopoiesis remain poorly defined.…”

Section: Introductionmentioning

confidence: 99%

Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2

et al. 2020

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“…Bone marrow granulomas (BMGs) caused by TB indicate an advanced stage with a high mortality in TB patients. [ 5 ] The incidence of BMGs was reported range from 0.3% to 3% and TB accounted for less than half of the cases in the low TB prevalence regions or years. [ 1 ] A series of 20 BMG cases by Feng et al [ 6 ] from the Peking Union Medical College Hospital in China reported that 60% of BMGs were caused by TB.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow granulomas in a high tuberculosis prevalence setting

Wang

Tang

et al. 2018

Medicine

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Granulomas were reported in 0.3% to 3% of bone marrow biopsies. The aim of the study was to evaluate the incidence and etiology of bone marrow granulomas (BMGs) in the West China Hospital, which located at a high tuberculosis (TB) prevalence area in China.A retrospective case review was performed on 11,339 bone marrow biopsies at the West China Hospital of Sichuan University between January 2011 and December 2015. Cases with BMGs were retrieved and their clinical data and histopathological features were collected, examined, and analyzed.Out of 11,339, 110 cases showed granulomatous lesions in the bone marrow biopsies (0.97%). Etiologies were indentified in 80 cases (72.8%), with infections being the most common (64.5%), following by malignancies (4.5%) and autoimmune diseases (3.6%). Among infectious cases, 87.32% (62/71) cases were diagnosed as TB, a positive acid-fast stain or/and polymerase chain reaction (PCR) result for mycobacterium TB DNA fragment amplification was obtained for 35 cases. In 30 cases (27.27%), a definite diagnosis could not be established.In a TB high prevalence region in China, with a combined histological, clinical, serological, and molecular approach, we were able to clarify the cause in 72.73% of the bone marrow granulomatous cases. TB is the most common underlying etiologies. Therefore, acid-fast stain and quantitative PCR for mycobacterium TB DNA amplification are recommended as a routine for bone marrow biopsies in TB high prevalence regions.

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La pancytopénie : une complication grave de la miliaire tuberculeuse

Cited by 12 publications

References 4 publications

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2

Bone marrow granulomas in a high tuberculosis prevalence setting

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