La silicotuberculose

Elkard, I.; Zaghba, N.; Benjelloun, H.; Bakhatar, A.; Yassine, N.

doi:10.1016/j.pneumo.2015.10.003

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…Pulmonary tuberculosis represents an important global public health problem and is the main silicosis comorbidity . Silica exposure is an important risk factor to Tb development, but none of the extrinsic factors related to silicosis development were associated with Tb in the present work (years of exposure to silica P = .902, hours of exposure to silica per week P = .936, and years since last exposure to silica P = .289). Smoking also showed no difference in the distribution between the groups ( P = .482).…”

Section: Discussionmentioning

confidence: 62%

“…The complications associated with crystalline silica inhalation go beyond silicosis. Individuals exposed to silica show 3.7 fold higher susceptibility to tuberculosis (Tb) than nonexposed subjects, while silicosis patients have approximately a 40 fold greater risk for Tb . However, the way that crystalline silica influences the pathogenicity of Mycobacterium tuberculosis (MTb) is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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Introduction: Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb).The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases.Methods: Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil.Results: No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A −899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). Conclusion:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis.However, additional studies are still needed to confirm these results.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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“…La lésion radiologique n'est pas spécifique, cependant, des lésions séquellaires y sont observées (atélectasies à droite). En effet, la tuberculose est citée dans la majorité des études comme l'une des principales complications de la silicose (Ellidrissi et al, 2016 ;Elkard et al, 2016 ;Heddane et al, 2019). D'autres complications comme le pneumothorax, l'insuffisance respiratoire chronique et le coeur pulmonaire chronique sont également très fréquemment rencontrés (Heddane et al, 2019), en sachant qu'elles sont toutes observées chez nos patients.…”

Section: Discussionunclassified

Silicose Classique Et Compliquée Chez Deux Jeunes Frères Lapidaires

Rakotondrasoa

Ravahatra

Tiaray

et al. 2020

ESJ

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“…Autopsy studies revealed that QIS is associated with pulmonary carcinoma, with positive correlation between Q exposure frequency and pulmonary cancer incidence. Lung pathology incidence increases if Q air concentration reaches 2mg/m3 [15,16,17,18,19,20,21] .…”

Section: Introductionmentioning

confidence: 99%

Incidence of pulmonary carcinogenic changes after one hundred weeks of solitary α-quartz exposure in albino Wistar rats (in vivo study)

Ahmed

2020

Egyptian Journal of Histology

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Introduction: Quartz is one of the most well-known compounds in earth crust which could be inhaled causing silicosis which is an occupational lung disease marked by pulmonary inflammation and scarring mainly in the upper lobes of the lungs. Many researchers linked between chronic repetitive quartz exposure and pulmonary histopathological changes in the form of hyperplasia and neoplastic lesions, but in our present study we aim to examine the carcinogenic effect of single exposure of quartz in two years period. Material and Methods: 80 Albino Wistar rats were divided into four groups. Q-60 and Q-100 groups received single dose of quartz (5 mg) by intratracheal injection and sacrificed after 60 and 100 weeks of exposure respectively. S-60 and S-100 groups received intratracheal 0.2 ml saline injection and sacrificed after 60 and 100 weeks of exposure respectively. Lungs were collected for histopathological and immunohistochemical studies. Results: Lung tissue of Q60 and Q100 showed inflammatory cells infiltrations, pulmonary edema and pulmonary fibrosis. Pulmonary edema and fibrosis are significantly apparent in Q60 than in Q 100. Q60 and S60 groups showed inflammatory cells infiltration but neither hyperplastic nor neoplastic changes were detected. Q100 and S100 groups showed inflammatory cells infiltration together with hyperplastic changes, adenoma, adenocarcinoma and papillomatous formation. Q100 group showed higher incidence of adenoma and adenocarcinoma if compared to S100, inflammatory cells infiltration was positively correlated with formation of hyperplastic and neoplastic changes. Examination of anti Napsin A and anti-CD-86 stained sections showed negative reaction in S60 and S100 groups while reaction in Q60 and Q100 groups was significantly strong positive. Conclusion:Our study revealed that quartz can be detected in lung tissue after two years of this solitary exposure inducing hyperplastic and precancerous lesions which could be reflected on quartz workers health.

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La silicotuberculose

Abstract: Silicosis increases the risk of tuberculosis, hence the importance of TB screening in all patients with silicosis.

Cited by 12 publications

References 25 publications

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Silicose Classique Et Compliquée Chez Deux Jeunes Frères Lapidaires

Incidence of pulmonary carcinogenic changes after one hundred weeks of solitary α-quartz exposure in albino Wistar rats (in vivo study)

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