Lab‐on‐a‐Chip Platforms for Disease Detection and Diagnosis

Işıksaçan, Ziya; Güler, Mustafa Tahsin; Kalantarifard, Ali; Asghari, Mohammad Hossein; Elbüken, Çağlar

doi:10.1002/9781119065036.ch8

Cited by 9 publications

(8 citation statements)

References 101 publications

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“…The physicians can sometimes be suspicious about the potential of the home-use of the point-of-care devices for two primary reasons [26]. (I) The patient might get an erroneous diagnostic result or no result at all due to wrong use of the device.…”

Section: Personal Prothrombin Time Measurementmentioning

confidence: 99%

“…The requirement to employ external components such as pumps, power sources, and control circuitry increases the cost and complexity of lab-on-a-chip platforms while limiting their portability [25]. Miniaturized integration of these components is desired to make these platforms appropriate for point-of-care use [26]. Apart from the frequently used pressure or syringe pumps, the liquid handling is aimed through micropumps categorized as non-mechanical (electrowetting, electrokinetic, electrochemical) and mechanical (rotary, peristaltic, diaphragm) [27,28].…”

Section: Introductionmentioning

confidence: 99%

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Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

Güler

Işıksaçan

Serhatlıoğlu

et al. 2018

Sensors and Actuators B: Chemical

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Coagulation is an essential physiological activity initiated by the interaction of blood components for clot formation. Prothrombin time (PT) measurement is a clinical test for the assessment of the extrinsic/common pathways of coagulation cascade. Periodic measurement of PT is required under numerous conditions including cardiovascular disorders. We present a self-powered microfluidic device for quantitative PT measurement from 50 μl whole blood. The entire platform is disposable and does not require any external pumping, power, or readout units. It consists of a 3D-printed effervescent pump for CO 2 generation from a chemical reaction, a cartridge for two-channel fluid flow (blood and water), and a grid for the quantification of fluid migration distance. Following the introduction of the fluids to the corresponding channel inlets, marking the coagulation start, an acid-base reaction is triggered for gas generation that drives the fluids within the channels. When the blood coagulates, its flow in the channel is halted. At that point, the distance water has travelled is measured using the grid. This distance correlates with PT as demonstrated through clinical tests with patient samples. This single-unit device has a potential for rapid evaluation and periodic monitoring of PT in the clinical settings and at the point-of-care.

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Section: Personal Prothrombin Time Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

Güler

Işıksaçan

Serhatlıoğlu

et al. 2018

Sensors and Actuators B: Chemical

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“…6,7 Presently, these parameters are rarely, if not at all, measured in clinics due to the drawbacks of using several benchtop instruments, requiring highly skilled and diversified workforce, lab space, high sample volume, operation time, and a large budget. 8 An all-at-once measurement approach also remains elusive thus far in the microfluidics community. There are only a few studies analyzing two parameters at a time based on image processing.…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Işıksaçan

Serhatlıoğlu

Elbüken

2020

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“…There are numerous reviews on droplet-based microfluidic systems focusing on droplet generation [9][10][11], droplet manipulation [12][13][14] and applications such as single cell analysis [15,16], biochemical detection [17] and synthetic biology [18]. Specifically, this review aims to summarize the label-free sensing systems demonstrated using microdroplets.…”

Section: Introductionmentioning

confidence: 99%

Label-Free Sensing in Microdroplet-Based Microfluidic Systems

2018

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Droplet microfluidic systems have evolved as fluidic platforms that use much less sample volume and provide high throughput for biochemical analysis compared to conventional microfluidic devices. The variety of droplet fluidic applications triggered several detection techniques to be applied for analysis of droplets. In this review, we focus on label-free droplet detection techniques that were adapted to various droplet microfluidic platforms. We provide a classification of most commonly used droplet platform technologies. Then we discuss the examples of various label-free droplet detection schemes implemented for these platforms. While providing the research landscape for label-free droplet detection methods, we aim to highlight the strengths and shortcomings of each droplet platform so that a more targeted approach can be taken by researchers when selecting a droplet platform and a detection scheme for any given application.

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Lab‐on‐a‐Chip Platforms for Disease Detection and Diagnosis

Cited by 9 publications

References 101 publications

Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

Self-powered disposable prothrombin time measurement device with an integrated effervescent pump

In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Label-Free Sensing in Microdroplet-Based Microfluidic Systems

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