Lab-on-a-Chip Technology and Its Applications

Yılmaz, Burak; Yılmaz, Fazilet

doi:10.1016/b978-0-12-804659-3.00008-7

Cited by 33 publications

(16 citation statements)

References 17 publications

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“…In this context, a new PoC technology, “Lab-on-a-Chip” (LOC), has been developed which integrates several laboratory assays in a single miniature device, including sampling procedure, preparation of the sample, detection and measurements of multiple biomarkers, and analysis [ 141 ]. The drawbacks of using a combination of biomarkers includes the complexity of interpreting the results and the manufacturing process, together with the considerable cost implications, which contradict the WHO’s ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable to end-users) for PoC devices [ 142 ].…”

Section: Detection Methods For Biomarkers In Periodontal Diseasesmentioning

confidence: 99%

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

et al. 2020

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Severe periodontitis is ranked as the sixth most prevalent disease affecting humankind, with an estimated 740 million people affected worldwide. The diagnosis of periodontal diseases mainly relies upon assessment of conventional clinical parameters. However, these parameters reflect past, rather than current, clinical status or future disease progression and, likely, outcome of periodontal treatment. Specific and sensitive biomarkers for periodontal diseases have been examined widely to address these issues and some biomarkers have been translated as point-of-care (PoC) tests. The aim of this review was to provide an update on PoC tests for use in the diagnosis and management of periodontal diseases. Among the PoC tests developed so far, active matrix metalloproteinase-8 has shown promising results in terms of diagnostic and prognostic values. However, further studies are required to increase the sensitivity and specificity via combining more than one biomarker and merging these test kits with periodontal risk assessment tools. Furthermore, the validity of these test kits needs to be investigated by applying the results in further independent studies and the impact on these test kits’, together with the results of risk factors for periodontal diseases, such as diabetes and smoking, also needs to be examined.

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Section: Detection Methods For Biomarkers In Periodontal Diseasesmentioning

confidence: 99%

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

et al. 2020

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“…This growing field has garnered considerable attention since scaled-down biochemical analysis has several key advantages over both conventional and current laboratory benchtop methods [ 3 , 5 ]. These advantages are consistently demonstrated in clinical medicine, engineering, biology, and life science, etc., for example, to expedite the experimental process by embracing automation and parallelization [ 1 , 8 , 9 ]; to lower the cost by reducing the volume of expensive reagents [ 1 , 5 , 10 , 11 ]; to yield better interpretation of experimental results by gleaning vital information at cellular even molecular levels [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Wearable Biosensors: From Healthcare Monitoring to Sports Analytics

Feng

Huang

et al. 2020

Biosensors

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Recent advances in lab-on-a-chip technology establish solid foundations for wearable biosensors. These newly emerging wearable biosensors are capable of non-invasive, continuous monitoring by miniaturization of electronics and integration with microfluidics. The advent of flexible electronics, biochemical sensors, soft microfluidics, and pain-free microneedles have created new generations of wearable biosensors that explore brand-new avenues to interface with the human epidermis for monitoring physiological status. However, these devices are relatively underexplored for sports monitoring and analytics, which may be largely facilitated by the recent emergence of wearable biosensors characterized by real-time, non-invasive, and non-irritating sensing capacities. Here, we present a systematic review of wearable biosensing technologies with a focus on materials and fabrication strategies, sampling modalities, sensing modalities, as well as key analytes and wearable biosensing platforms for healthcare and sports monitoring with an emphasis on sweat and interstitial fluid biosensing. This review concludes with a summary of unresolved challenges and opportunities for future researchers interested in these technologies. With an in-depth understanding of the state-of-the-art wearable biosensing technologies, wearable biosensors for sports analytics would have a significant impact on the rapidly growing field—microfluidics for biosensing.

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“…The fabrication process of these devices has been covered elsewhere [16,17,18,19], and hence will not be detailed in this review. As polymer science and micro/nanofabrication technologies have been advancing, a wide range of LOC devices have emerged for different applications including diagnostics, proteomics, metabolomics, genomics [4,14,20], (bio)analytical chemistry [21,22,23,24], organic chemistry [25,26], environmental monitoring [27,28], fuel cells [29], biodefence [30], as well as the monitoring of food safety and quality [31,32,33].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Dervisevic

Tuck

Voelcker

et al. 2019

Sensors

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Lab-on-a-chip sensing technologies have changed how cell biology research is conducted. This review summarises the progress in the lab-on-a-chip devices implemented for the detection of cellular metabolites. The review is divided into two subsections according to the methods used for the metabolite detection. Each section includes a table which summarises the relevant literature and also elaborates the advantages of, and the challenges faced with that particular method. The review continues with a section discussing the achievements attained due to using lab-on-a-chip devices within the specific context. Finally, a concluding section summarises what is to be resolved and discusses the future perspectives.

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Lab-on-a-Chip Technology and Its Applications

Cited by 33 publications

References 17 publications

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

Recent Progress in Wearable Biosensors: From Healthcare Monitoring to Sports Analytics

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

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