Label-free biosensing using cascaded double-microring resonators integrated with microfluidic channels

Chen, Yangqing; Fang, Yu; Yang, Chang; Song, Jinyan; Tang, Longhua; Li, Mingyu; He, Jian‐Jun

doi:10.1016/j.optcom.2015.01.028

Cited by 37 publications

(18 citation statements)

References 26 publications

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“…For example, human immunoglobulin G (IgG) has been detected in microfluidic devices by detecting the refraction index change which was caused by the binding of secondary antibodies. This platform can be used in specific configured IgG detection for certain diseases diagnosis . Moreover, specific antibody to Helicobacter pylori (the main pathogens in enteritis) has also detected on a laser‐assisted microfluidic system for enteritis diagnosis ( Figure A) .…”

Section: Immunodiagnosis Studies On Microfluidic Chipsmentioning

confidence: 99%

Analysis of Leukocyte Behaviors on Microfluidic Chips

Yang

Cao

2019

Adv Healthcare Materials

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The orchestration of massive leukocytes in the immune system protects humans from invading pathogens and abnormal cells in the body. So far, researches focusing on leukocyte behaviors are performed based on both in vivo and in vitro models. The in vivo animal models are usually less controllable due to their extreme complexity and nonignorable species issue. Therefore, many researchers turn to in vitro models. With the advances in micro/nanofabrication, the microfluidic chip has emerged as a novel platform for model construction in multiple biomedical research fields. Specifically, the microfluidic chip is used to study leukocyte behaviors, due to its incomparable advantages in high throughput, precise control, and flexible integration. Moreover, the small size of the microstructures on the microfluidic chip can better mimic the native microenvironment of leukocytes, which contributes to a more reliable recapitulation. Herein are reviewed the recent advances in microfluidic chip–based leukocyte behavior analysis to provide an overview of this field. Detailed discussions are specifically focused on host defense against pathogens, immunodiagnosis, and immunotherapy studies on microfluidic chips. Finally, the current technical challenges are discussed, as well as possible innovations in this field to improve the related applications.

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Section: Immunodiagnosis Studies On Microfluidic Chipsmentioning

confidence: 99%

Analysis of Leukocyte Behaviors on Microfluidic Chips

Yang

Cao

2019

Adv Healthcare Materials

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“…Purely dielectric micro-rings and disks have been proposed and widely investigated as nano-sensors during the last decade. 1,[62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] These systems are very good candidates for the integration on a compact chip. Here several rings can work in parallel in a multiplex architecture.…”

Section: Hybrid Wgm Ring and Disks For Bulk Refractive Index And Surfmentioning

confidence: 99%

“…In these cases the surface of the ring has to be properly functionalized. 1,62,63,65,66,68,69,71,[74][75][76][77]80 Two examples of bulk refractive index sensing (with a solution of water and sodium chloride) and surface binding (with the biotin/ streptavidin complex) are reported in Fig. 8.…”

Section: Hybrid Wgm Ring and Disks For Bulk Refractive Index And Surfmentioning

confidence: 99%

Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review

Bozzola

Perotto

Angelis

2017

Analyst

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“…Photonic integrated circuits are now playing a role in advanced technologies with applications ranging from atmospheric spectroscopy [2] and medical diagnostics [3][4][5][6][7] to telecommunications [8,9], data centers, [10,11] and supercomputers [12,13]. Each of these integrated photonic application spaces opens new possibilites for science and technology.…”

Section: Introductionmentioning

confidence: 99%

Room-temperature-deposited dielectrics and superconductors for integrated photonics

Shainline¹,

Buckley²,

Nader³

et al. 2017

Opt. Express

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We present an approach to fabrication and packaging of integrated photonic devices that utilizes waveguide and detector layers deposited at near-ambient temperature. All lithography is performed with a 365 nm i-line stepper, facilitating low cost and high scalability. We have shown low-loss SiN waveguides, high-Q ring resonators, critically coupled ring resonators, 50/50 beam splitters, Mach-Zehnder interferometers (MZIs) and a process-agnostic fiber packaging scheme. We have further explored the utility of this process for applications in nonlinear optics and quantum photonics. We demonstrate spectral tailoring and octave-spanning supercontinuum generation as well as the integration of superconducting nanowire single photon detectors with MZIs and channel-dropping filters. The packaging approach is suitable for operation up to 160 • C as well as below 1 K. The process is well suited for augmentation of existing foundry capabilities or as a stand-alone process.

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Label-free biosensing using cascaded double-microring resonators integrated with microfluidic channels

Cited by 37 publications

References 26 publications

Analysis of Leukocyte Behaviors on Microfluidic Chips

Analysis of Leukocyte Behaviors on Microfluidic Chips

Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review

Room-temperature-deposited dielectrics and superconductors for integrated photonics

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