Label-free electrochemical biosensor for determination of procalcitonin based on graphene-wrapped Co nanoparticles encapsulated in carbon nanobrushes coupled with AuPtCu nanodendrites

Ge, Xin-Yue; Zhang, Jingxian; Wang, Ai‐Jun; Mei, Li-Ping; Feng, Jiu‐Ju

doi:10.1007/s00604-022-05179-8

Cited by 26 publications

(10 citation statements)

References 58 publications

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“…33 diagnosis of sepsis, and compared to similar systems, the nanocomposite developed in this study had a simple and low-cost preparation method. 41 PCT was determined with linearity and acceptable LOD using the electrochemical impedance spectroscopy (EIS) technique.…”

Section: De Veloped B I Os En Sor S For De Tec Ti On Of P C Tmentioning

confidence: 99%

Nanobiosensors for procalcitonin (PCT) analysis

Mobed,

Darvishi,

Tahavvori

et al. 2024

Clinical Laboratory Analysis

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BackgroundProcalcitonin (PCT) is a critical biomarker that is released in response to bacterial infections and can be used to differentiate the pathogenesis of the infectious process.ObjectiveIn this article, we provide an overview of recent advances in PCT biosensors, highlighting different approaches for biosensor construction, different immobilization methods, advantages and roles of different matrices used, analytical performance, and PCT biosensor construction. Also, we will explain PCT biosensors sensible limits of detection (LOD), linearity, and other analytical characteristics. Future prospects for the development of better PCT biosensor systems are also discussed.MethodsTraditional methods such as capillary electrophoresis, high‐performance liquid chromatography, and mass spectrometry are effective in analyzing PCT in the medical field, but they are complicated, time‐consuming sample preparation, and require expensive equipment and skilled personnel.ResultsIn the past decades, PCT biosensors have emerged as simple, fast, and sensitive tools for PCT analysis in various fields, especially medical fields.ConclusionThese biosensors have the potential to accompany or replace traditional analytical methods by simplifying or reducing sample preparation and making field testing easier and faster, while significantly reducing the cost per analysis.

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Section: De Veloped B I Os En Sor S For De Tec Ti On Of P C Tmentioning

confidence: 99%

Nanobiosensors for procalcitonin (PCT) analysis

Mobed,

Darvishi,

Tahavvori

et al. 2024

Clinical Laboratory Analysis

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“…Detection method Linear range Detection limit References G-Co@ NCNBs GCE One-pot solvothermal strategy and self-catalyzed chemical vapor deposition 0.0001 ~ 100 ng mL −1 0.01 pg mL −1 [54] rGO-Au GCE Electrodeposition 1.00 pg mL -1 to 2.00×101 ng mL -1 0.43 pg mL…”

Section: Substratementioning

confidence: 99%

Development of conducting paper-based electrochemical biosensor for procalcitonin detection

Gupta¹

2023

ADMET DMPK

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In the present research, an advanced cellulose fiber paper (CFP) based biosensor is developed. This sensor is modified with nanocomposites containing poly(3,4-ethylene dioxythiophene) polystyrene sulfonate (PEDOT:PSS) as the main matrix and functionalized gold nanoparticles (PEDOT:PSS-AuNP@CFP) for the selective and sensitive detection of bacterial infection (BI)-specific biomarker procalcitonin (PCT). Scanning electronic microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction are used to characterize the PEDOT:PSS-AuNP nanocomposite. This biosensor exhibits a high sensitivity of 1.34 μA /pg mL-1 in the linear detection ranges of 1 -20 × 104 pg mL-1, and a 24-day life span for PCT antigen detection. Anti-PCT antigenic protein is used for immobilization for PCT quantification. The results of electrochemical response studies showed that this conductive paper bioelectrode had good reproducibility, stability, and sensitivity in physiological ranges (1 -20 ×104 pg mL-1). Further, the proposed bioelectrode is an alternative choice for point-of-care PCT detection.

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“…They developed a label-free electrochemical immunosensor based on the synergic effect of two different nanostructures the AuPtCu nanodendrites coupled with graphene-wrapped Co nanoparticles encapsulated in 3D N-doped carbon nanobrushes used to modify the electrode surface. These nanostructures have improved both the antibody loading capacity of the electrode and the mass/electron transport catalyzing the H 2 O 2 reduction, reaching an ultra-low LOD around 0.011 pg/mL in diluted serum samples [ 69 ].…”

Section: Biosensor As An Alternative Device For Sepsismentioning

confidence: 99%

Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

et al. 2022

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Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management. Biosensing systems represent a valid alternative due to their characteristics such as low cost, portability, low response time, ease of use and suitability for point of care/need applications. This review provides an overview of the infectious agents associated with the development of sepsis and the host biomarkers suitable for diagnosis and prognosis. Special focus is given to the new emerging biosensing technologies using electrochemical and optical transduction techniques for sepsis diagnosis and management.

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Label-free electrochemical biosensor for determination of procalcitonin based on graphene-wrapped Co nanoparticles encapsulated in carbon nanobrushes coupled with AuPtCu nanodendrites

Cited by 26 publications

References 58 publications

Nanobiosensors for procalcitonin (PCT) analysis

Nanobiosensors for procalcitonin (PCT) analysis

Development of conducting paper-based electrochemical biosensor for procalcitonin detection

Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

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