Laboratory analysis of patients with SARS-CoV-2 Infection in a semi-urban COVID-19 center of Lucknow, India

Abstract

Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus infection (COVID-19) can assist with clinical diagnosis and prognosis. This study is a collection of clinical data from 100 hospitalized patients diagnosed with COVID-19 in a dedicated COVID- 19 health center located in a semi-urban area from July to September, 2020. The average age of the patients was 50 years. The proportion of patients with comorbidities was 59%. Lymphocyte counts were reduced in the routine blood-work for all patients, but significantly lower in L2-type patients. Elevation of D-Dimer with near normal PT and APTT were detected in coagulation function tests, and more significant changes were observed in L2-type patients compared to L1-type patients. Serum ferritin levels were sensitive to SARS-CoV (severe acute respiratory syndrome coronavirus-2) infection and found to rise in L2-type patients more than L1-type patients. Inflammatory markers, CRP and Interleukin-6 (IL-6) were significantly increased in all patients, but higher in L2-type patients compared to L1-type patients. Coming to organ damage, kidney injury was the most common organ affected by COVID-19 followed by heart and liver.