Laboratory information management system for COVID-19 non-clinical efficacy trial data

Abstract

Background As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus disease 2019 (COVID-19) pandemic, a number of global efforts are underway to develop vaccines and therapeutics. We are therefore observing an explosion in the proliferation of COVID-19 data, and interoperability is highly requested in multiple institutions participating simultaneously in COVID-19 pandemic research. Results In this study, a laboratory information management system (LIMS) approach has been adopted to systemically manage various COVID-19 non-clinical trial data, including mortality, clinical signs, body weight, body temperature, organ weights, viral titer (viral replication and viral RNA), and multiorgan histopathology, from multiple institutions based on a web interface. The main aim of the implemented system is to integrate, standardize, and organize data collected from laboratories in multiple institutes for COVID-19 non-clinical efficacy testings. Six animal biosafety level 3 institutions proved the feasibility of our system. Substantial benefits were shown by maximizing collaborative high-quality non-clinical research. Conclusions This LIMS platform can be used for future outbreaks, leading to accelerated medical product development through the systematic management of extensive data from non-clinical animal studies.

The Implementation of Enterprise Resource Planning Informatics Department Education Laboratory

“…Laboratory Management Information Systems (LIMS) facilitate efficient resource management in educational laboratories. LIMS has been used for applications in a variety of settings, including healthcare laboratories for Covid-19 test data management (Yoon et al, 2022), biosafety (Sun et al, 2021), clinics (Fu et al, 2023), science research centers in Portugal (Bordalo et al, 2021), even the Republic of Indonesia's National Narcotics Agency (Dimas Nugroho & Mursanto, 2019). LIMS also helps manage resources at universities, as has been implemented by Telkom University (Eskaluspita, 2020), Indonesian Education University (Fushshilat et al, 2018), Kufa University -Iraq (Hadi et al, 2023), and Muhammadiyah Metro University -Lampung (Riswanto et al, 2019).…”

Biosafety protection and workflow of clinical microbiology laboratory under COVID-19: A review

“…[23][24][25][26][27][28][29][30][31][32][33] Therefore, personal safety of medical personnel is important for prevention and control. [34][35][36][37][38][39][40][41][42][43][44][45] According to the relevant documents, guidelines and other materials and the working experience of the designated hospital, and in combination with the current situation of the existing sites, equipment, facilities and personnel of the Department, the corresponding prevention, and control plan is formulated. [46,47] From the perspective of the laboratory, this paper discusses how to do a good job in biosafety protection, improve biosafety protection measures, and optimize the workflow.…”