Laboratory-on-a-Smartphone

Mitsushio, Masaru

doi:10.2116/analsci.highlights2002

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Nowadays, the spectrophotometric method can be performed by using smartphone systems to reduce expensive cost, easy to use because their operating system is the smallest and portable. [20][21][22][23][24] As well, its camera lenses are high-quality hardware to evaluate colorimetric or light intensity via Complementary Metal Oxide Semiconductor (CMOS). 25,26 For instance, M. Á. Aguirre et al, developed the smartphone application for ibuprofen analysis in commercial tablets.…”

Section: Introductionmentioning

confidence: 99%

A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples

Khachornsakkul

Dungchai

2020

ANAL. SCI.

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The simple reflective absorbance spectrophotometric smartphone device for point-ofmonitoring amlodipine is presented here for the first time. The immediate analysis of amlodipine in the human urine of the patients who suffered severe side effects of this drug is very important for diagnosis, treatment, and reduction of the death rate. This measurement technique is based on the charge-transfer complex between amlodipine and picric acid, which forms a yellow product. This product can absorb light intensity from an LED strip and measure through the Blue channel from RGB mode with a smartphone application. The linear relationship for amlodipine monitoring was found in a wide range from 100.0 µg L-1 to 140.0 mg L-1 (R 2 = 0.999), and the limit of detection was found to be 25.0 µg L-1. Our proposed method can be applied to the different smartphone brands with consistent sensitivity of amlodipine detection. Additionally, the determination of amlodipine in pharmaceutical formulation and human urine samples was demonstrated by our proposed method. The recoveries were indicated in the range 98.60-100.00%, which is at the acceptable level for pharmacy. This method offers interweave of basic technology and chemical analysis with environmentally friendly due to reducing the complex instrument and the amount of organic waste compared to chromatographic technique and efficient use for the detection of amlodipine. Hence, this method can be applied for promptly medical diagnoses and laboratories with limited budget resources.

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