2019
DOI: 10.1097/qai.0000000000001899
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Laboratory-Reflex Cryptococcal Antigen Screening Is Associated With a Survival Benefit in Tanzania

Abstract: 26This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. ABSTRACTBackground: Cryptococcal antigen (CrAg) screening in persons with advanced HIV/AIDS is recommended to prevent death. Implementing CrAg screening only in outpatients may underestimate … Show more

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Cited by 22 publications
(20 citation statements)
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“…Thirteen studies reported the prevalence of TB disease among patients who were CrAg positive, using different TB screening approaches [ 9 , 11 , 19–22 , 26 , 28 , 33 , 41 , 46 , 57 , 72 ]. Among 234 patients screened CrAg positive, 45 also were diagnosed with TB, giving an overall prevalence of coexistent disease of 19.2% (95% CI, 14.4%–24.9%).…”
Section: Resultsmentioning
confidence: 99%
“…Thirteen studies reported the prevalence of TB disease among patients who were CrAg positive, using different TB screening approaches [ 9 , 11 , 19–22 , 26 , 28 , 33 , 41 , 46 , 57 , 72 ]. Among 234 patients screened CrAg positive, 45 also were diagnosed with TB, giving an overall prevalence of coexistent disease of 19.2% (95% CI, 14.4%–24.9%).…”
Section: Resultsmentioning
confidence: 99%
“…The median CD4 cell count was 31 cells/µL (IQR 13‐59), and the median baseline CSF fungal burden was a relatively low 19 000 CFU/mL (IQR, 800‐110 000). In the presence of a district‐wide CrAg screening programme testing peripheral blood, the time from entry into HIV care to lumbar puncture and CSF CrAg result was a median of 1 (IQR, 0, 2) days …”
Section: Resultsmentioning
confidence: 99%
“…In the presence of a district-wide CrAg screening programme testing peripheral blood, the time from entry into HIV care to lumbar puncture and CSF CrAg result was a median of 1 (IQR, 0, 2) days. 13 The 2-week survival was 64% (18/28) for patients receiving fluconazole + sertraline and 89% (16/18) for those receiving additional amphotericin (P = .09). The 10-week survival was 21% (6/28) with fluconazole + sertraline alone, and 10-week survival was significantly higher at 61% (11/18) with 5 days of added amphotericin (P = .012).…”
Section: Outcomes and Statistical Methodsmentioning
confidence: 94%
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