Lack of association between serum antibodies of <i>Chlamydia pneumoniae</i> infection and the risk of lung cancer

Smith, Jennifer S.; Kumlin, Urban; Nyberg, Fredrik; Fortes, Cristina; Заридзе, Давид; Ahrens, Wolfgang; Brüske‐Hohlfeld, Irene; Constantinescu, Vali; Ting, Jie; Benhamou, Simone; Simonato, Lorenzo; Boman, Jens; Gaborieau, Valérie; Boffetta, Paolo

doi:10.1002/ijc.23814

Cited by 17 publications

(14 citation statements)

References 16 publications

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“…It has been reported that former smokers that are infected have a larger risk of lung cancer than current smokers, but there were no never smokers included in this study (163). A recent report examining chlamydial immunoglobulin titers in 90 never smokers (defined here as <400 lifetime cigarettes smoked) with lung cancer and 68 never-smoking controls found no evident association between infection and cancer, but the power of this study was clearly suboptimal (164). …”

Section: Risk Factorsmentioning

confidence: 62%

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors

Samet

Ávila-Tang

Boffetta

et al. 2009

Clinical Cancer Research

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464

321

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More than 161,000 lung cancer deaths are projected to occur in the U.S. in 2008. Of these, an estimated 10–15% will be caused by factors other than active smoking, corresponding to 16,000–24,000 deaths annually. Thus lung cancer in never smokers would rank among the most common causes of cancer mortality in the U.S. if considered to be a separate category. Slightly more than half of the lung cancers caused by factors other than active smoking occur in never smokers. As summarized in the accompanying article, lung cancers that occur in never smokers differ from those that occur in smokers in their molecular profile and response to targeted therapy. These recent laboratory and clinical observations highlight the importance of defining the genetic and environmental factors responsible for the development of lung cancer in never-smokers. This article summarizes available data on the clinical epidemiology of lung cancer in never smokers, and the several environmental risk factors that population-based research has implicated in the etiology of these cancers. Primary factors closely tied to lung cancer in never smokers include exposure to known and suspected carcinogens including radon, second-hand tobacco smoke, and other indoor air pollutants. Several other exposures have been implicated. However, a large fraction of lung cancers occurring in never-smokers cannot be definitively associated with established environmental risk factors, highlighting the need for additional epidemiologic research in this area.

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Section: Risk Factorsmentioning

confidence: 62%

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors

Samet

Ávila-Tang

Boffetta

et al. 2009

Clinical Cancer Research

Self Cite

464

321

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“…Many clinical epidemiological studies analyzing the association between Cpn infection and the risk of lung cancer have been reported (Jackson et al, 2000;Koyi et al, 2001;Anttila et al, 2003;Kocazeybek, 2003;Littman et al, 2004;Littman et al, 2005;Chaturvedi et al, 2010), but no clear consensus has been reached (Koh et al, 2005;Sessa et al, 2008;Smith et al, 2008). This relationship was assessed more closely by performing a meta-analysis (Zhan et al, 2011) based on publications collected from electronic databases such as Pubmed, Embase, Web of Science, and CNKI.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chu

Guo²,

Pan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The association of C. pneumoniae infection with lung cancer risk has been variable in previous studies, with relative risk estimates ranging from 0.7 to 9.0 among seropositive individuals (7)(8)(9)(10)(11)(12)(13). This wide variability in Chlamydia-related lung cancer risk could reflect the retrospective nature of some studies, small sample sizes, or inadequate adjustment for confounding due to smoking (10).…”

Section: Introductionmentioning

confidence: 99%

Chlamydia pneumoniaeInfection and Risk for Lung Cancer

Chaturvedi

Gaydos

Agreda

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We evaluated the relationship of Chlamydia pneumoniae infection with prospective lung cancer risk using traditional serologic markers [microimmunoflourescence (MIF) IgG and IgA antibodies] and Chlamydia heat shock protein-60 (CHSP-60) antibodies, a marker for chronic chlamydial infection.Methods: We conducted a nested case-control study (593 lung cancers and 671 controls) within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (N = 77,464). Controls were matched to cases by age, sex, randomization year, follow-up time, and smoking (pack-years of smoking, time since quitting). We assessed C. pneumoniae seropositivity and endpoint antibody titers (IgG and IgA against C. pneumoniae elementary bodies and IgG against CHSP-60).Results: C. pneumoniae seropositivity by microimmunoflourescence IgG or IgA antibodies was not associated with lung cancer [odds ratio of 0.88 and 95% confidence interval (95% CI) of 0.69-1.13 for IgG; odds ratio of 0.98 and 95% CI of 0.75-1.27 for IgA]. In contrast, individuals seropositive for CHSP-60 IgG antibodies had significantly increased lung cancer risk (odds ratio, 1.30; 95% CI, 1.02-1.67), and risk increased with increasing antibody titers (P trend = 0.006). CHSP-60-related risk did not differ significantly by lung cancer histology, follow-up time, or smoking. CHSP-60 seropositivity was associated with increased risk 2 to 5 years before lung cancer diagnosis (odds ratio, 1.77; 95% CI, 1.16-2.71; P trend = 0.006), thus arguing against reverse causality.Conclusions: CHSP-60 seropositivity and elevated antibody titers were associated with significantly increased risk for subsequent lung cancer, supporting an etiologic role for C. pneumoniae infection in lung carcinogenesis.Impact: Our results highlight the potential for lung cancer risk reduction through treatments targeted toward C. pneumoniae infections and chronic pulmonary inflammation. Cancer Epidemiol Biomarkers Prev; 19(6);

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Lack of association between serum antibodies of Chlamydia pneumoniae infection and the risk of lung cancer

Cited by 17 publications

References 16 publications

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors

Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

Chlamydia pneumoniaeInfection and Risk for Lung Cancer

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