Lack of Correlation between Number of Antiretinal Antibodies and Clinical Outcome Measures in Autoimmune Retinopathy Patients

Stanwyck, Lynn K.; Moussa, Kareem; Chan, Weilin; Aitken, Phil A.; Sobrin, Lucia

doi:10.1016/j.oret.2019.06.007

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…18 Because serum AAbs can also be found in normal individuals, the presence of AAbs, together with clinical and electrophysiological evidence of retinal degeneration, constitutes the diagnosis of AIR. [19][20][21] Autoimmune-related retinopathy and optic neuropathy syndrome is also characterized by AAb against retinal or ON antigens in the absence of cancer. 22 These AAbs probably cause additional vision loss through an ON-related component in AIR.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune-Related Retinopathy Presenting As Plaquenil Toxicity in Patients With Systemic Lupus Erythematosus

Ma,

Sarici,

Iannaccone

et al. 2023

Journal of VitreoRetinal Diseases

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Purpose: To report 3 cases of autoimmune retinopathy (AIR) in patients with systemic lupus erythematosus (SLE) to explore the association between these conditions and highlight additional clinical consideration of AIR in patients presenting with atypical retinopathy in the context of hydroxychloroquine use. Methods: The medical and clinical follow-up records of 3 clinical cases were reviewed. The eligibility criteria were the absence of other retinopathy or systemic autoimmune diseases. Results: All patients had a long-standing diagnosis of SLE and had been taking hydroxychloroquine at a dose exceeding the American Academy of Ophthalmology recommendations. All 3 patients had extensive retinal degeneration atypical in appearance for drug toxicity alone. Examination, imaging, electroretinograms, and autoantibody assays eventually led to the diagnosis of AIR. Conclusions: Further study of the AIR and SLE may reveal an association between these conditions. In patients with SLE presenting with retinal degeneration, AIR may be underdiagnosed.

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Section: Discussionmentioning

confidence: 99%

Autoimmune-Related Retinopathy Presenting As Plaquenil Toxicity in Patients With Systemic Lupus Erythematosus

Ma,

Sarici,

Iannaccone

et al. 2023

Journal of VitreoRetinal Diseases

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“…They also concluded that ARAs were not a biomarker for response to treatment. 24,25 In review, Fox et al developed consensus among uveitis specialists in the American Uveitis Society, concluding that there is not enough evidence to determine whether the number of positive ARAs or any specific subtypes are clinically relevant. 16 Our study did not show significant correlation between ARA titers or numbers and VA, subjective vision, or investigations including ff-ERG parameter and MD in HVF.…”

Section: Discussionmentioning

confidence: 99%

Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy

Rujkorakarn¹,

Margolis²,

Morvey³

et al. 2023

OPTH

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To assess the possible correlation of anti-retinal antibody titers and number of anti-retinal antibodies with outcome measurements including visual acuity, subjective vision loss, visual field, and electroretinography in patients with autoimmune retinopathy. Design: Single-center, retrospective cross-sectional study. Patients and Methods: Patients with autoimmune retinopathy who underwent anti-retinal antibody testing at least twice during their follow-up were enrolled. Anti-retinal antibody titers and numbers were grouped as improved, stable, or worsened. Outcomes included Snellen visual acuity, patient-reported vision loss, Humphrey visual field mean deviations, and electroretinography parameters.Results: Thirty-one eyes among 16 patients with autoimmune retinopathy were included. Between-group analyses of visual acuity, subjective vision loss, visual field, and electroretinography outcomes did not reveal any significant differences by anti-retinal antibody titer or number group at a 95% confidence interval. Conclusion: Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated antiretinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.

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“…ARAs can target any type of cell in the retina, including photoreceptors, ganglion cells, or bipolar cells. However, the presence of these antibodies alone is not sufficient to diagnose AIR, as they can also be found in a variety of systemic autoimmune diseases, as well as in healthy patients [1,5,11].…”

Section: Pathophysiologymentioning

confidence: 99%

“…However, the presence of these antibodies alone is not sufficient to diagnose AIR, as they can also be found in a variety of systemic autoimmune diseases, as well as in healthy patients. ( 1 , 5 , 11 )…”

Section: Pathophysiologymentioning

confidence: 99%

“…Although most experts believe the detection of ARA is a requirement for the diagnosis of AIR, others believe that they are possibly an epiphenomenon related to the disease, without direct pathogenicity. ( 8 , 11 , 18 ) Furthermore, some authors believe that the simple detection of the antibody is not sufficient for the diagnosis of AIR nor does it prove that that antibody found is pathogenic. ( 1 ) On the other hand, the absence of ARAs also does not rule out the diagnosis.…”

Section: Anti-retina Auto-antibodies and Controversiesmentioning

confidence: 99%

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Autoimmune Retinopathy, Testing, and Its Controversies

Roisman

Rossetto

Goldhardt

2021

Curr Ophthalmol Rep

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Purpose of ReviewThe purpose of this revision is to sumarize the most important clinical features of the autoimune retinopathies (AIRs). Recent Findings AIRs are a group of inflammatory conditions affecting the retina characterized by progressive unexplained visual loss, abnormalities and contraction in visual fields, photoreceptor and electroretinographic dysfunction, and the presence of circulating anti-retinal antibodies. The pathogenesis of AIR remains unclear and various antiretinal antibodies have been associated to the disease. The diagnosis of AIR is based on a particular clinical presentation along with the detection of serum antiretinal antibodies. Numerous anti-inflammatory therapeutic alternatives have been described for the treatment of AIR; nevertheless, there is no consensus on treatment protocol. Summary Because of its association with different types of malignant tumors, the early diagnosis, multi-disciplinary approach, and prompt treatment should be warranted. Keywords Autoimmune retinopathy • Cancer-associated retinopathy • Melanoma-associated retinopathy • Anti-retinal antibodiesThis article is part of the Topical Collection on Retina * Luiz Roisman

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Lack of Correlation between Number of Antiretinal Antibodies and Clinical Outcome Measures in Autoimmune Retinopathy Patients

Cited by 8 publications

References 5 publications

Autoimmune-Related Retinopathy Presenting As Plaquenil Toxicity in Patients With Systemic Lupus Erythematosus

Autoimmune-Related Retinopathy Presenting As Plaquenil Toxicity in Patients With Systemic Lupus Erythematosus

Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy

Autoimmune Retinopathy, Testing, and Its Controversies

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