Lactate as a Biomarker for Sleep

Naylor, Erik; Aillon, Daniel V.; Barrett, Brian S.; Wilson, George S.; Johnson, David A.; Johnson, Donna A.; Harmon, Hans; Gabbert, Seth; Petillo, Peter A.

doi:10.5665/sleep.2072

Cited by 84 publications

(124 citation statements)

References 50 publications

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“…All previous work for this purpose has been performed in fruit flies, mice, and rats respectively, but not humans. 12,13,15,16) Thus, system test in animals or clinical trials seem to have become very important in future.…”

Section: Discussionmentioning

confidence: 99%

“…According to previous report, high- level of lactate will keep awaking situation. 15) THSG reduced lactate level by inhibiting LDH activity and would promote sleep homeostasis.…”

Section: The Effects Of Thsg On Sleep Patterns Of Micementioning

confidence: 99%

“…13) Extracellular lactate concentration is associated with survival and neurologic outcome in patients with cardiac arrest 14) and another reliable sleep component. 15) Rapid and sustained increases in cortical lactate concentration can be immediately observed during waking and REM sleep. Elevated lactate concentration is also maintained throughout a period of continuous waking.…”

mentioning

confidence: 99%

“…Elevated lactate concentration is also maintained throughout a period of continuous waking. 15) A sustained decline in lactate concentration was measured during NREM sleep. The similar results were reported in other paper: lactate progressively increases during waking and REM sleep and decreases during NREM sleep.…”

mentioning

confidence: 99%

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Stilbene Glucoside, a Putative Sleep Promoting Constituent from <i>Polygonum multiflorum</i> Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

Qian

et al. 2017

Chem. Pharm. Bull.

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Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented. Electroencephalogram (EEG) and electromyogram (EMG) electrodes were implanted to determine sleep-wake state. RT-PCR and Western blot was used to measure the levels of lactate dehydrogenase (LDH) and saliva alpha amylase. Spearman's rank correlation coefficient was used to identify the strength of correlation between the variables. The results showed that THSG significantly prolonged the sleep time of the mice (p<0.01). THSG changed sleep profile by reducing wake and rapid eye movement (REM) period, and increasing non-REM period. RT-PCR and Western blot analysis showed that THSG could down-regulate the levels of LDH and saliva alpha amylase ( p<0.05). The level of lactate and glucose was positively related with the activity of LDH and saliva alpha amylase (p<0.05), respectively. On the other hand, the activities of LDH and amylase were negatively associated with sleep duration ( p<0.05). The levels of lactate and glucose affect sleep homeostasis. Thus, THSG may prevent insomnia by regulating sleep duration via LDH and salivary alpha amylase.

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Section: Discussionmentioning

confidence: 99%

“…According to previous report, high- level of lactate will keep awaking situation. 15) THSG reduced lactate level by inhibiting LDH activity and would promote sleep homeostasis.…”

Section: The Effects Of Thsg On Sleep Patterns Of Micementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Stilbene Glucoside, a Putative Sleep Promoting Constituent from <i>Polygonum multiflorum</i> Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

Qian

et al. 2017

Chem. Pharm. Bull.

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“…Previous attempts at simultaneous electrocorticography (ECoG) and neurochemical signal recordings were based on the use of multiple, separate electrodes, which limits spatial and temporal resolution since separate sensors are not located within the same microenvironment (Dash et al, 2009;Naylor et al, 2011;Odijk et al, 2015;Rogers et al, 2013). Consequently, the development of a single probe capable of simultaneously detecting electrical and chemical signals is of great significance.…”

Section: Introductionmentioning

confidence: 99%

Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography

Limnuson

et al. 2016

Biosensors and Bioelectronics

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We report a novel single neural probe for real-time simultaneous monitoring of multiple neurochemicals and direct-current electrocorticography (DC-ECoG). A major advance of this probe is the inclusion of two iridium oxide reference electrodes to improve sensor accuracy. The ECoG reference electrode is identical to the ECoG recording electrodes to significantly improve DC stability, while the reference for electrochemical sensors has 10-fold lower polarization rate to minimize the small current-induced drift in the reference electrode potential. In vitro, the single probe selectively measured oxygen (r(2)=0.985 ± 0.01, concentration range=0-60 mmHg, limit of detection=0.4 ± 0.07 mmHg) and glucose (r(2)=0.989 ± 0.009, concentration range=0-4mM, limit of detection=31 ± 8 µM) in a linear fashion. The performance of the single probe was assessed in an in vivo needle prick model to mimic sequelae of traumatic brain injury. It successfully monitored the theoretically expected transient brain oxygen, glucose, and DC potential changes during the passage of spreading depolarization (SD) waves. We envision that the developed probe can be used to decipher the cause-effect relationships between multiple variables of brain pathophysiology with the high temporal and spatial resolutions that it provides.

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Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

2018

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Chemical analyses of brain interstitial fluid can reveal important information about local brain metabolism and neurochemistry, and can enhance our understanding of how neuronal networks respond to physiological or pathological stimuli. Among brain monitoring methods currently available, microelectrode biosensors provide real‐time analyses with high temporal resolution and minimal perturbation to living tissue by using oxidase enzymes for biological recognition. Two types of microelectrodes are used: cylindrically shaped wire electrodes provide the smallest implantable devices to date, and microfabricated multi‐electrode needles can monitor several molecules simultaneously. They have already contributed significantly to our understanding of brain energy metabolism with glucose and lactate detection, and to neurotransmitter systems with glutamate, D‐serine, acetylcholine, and purine detection. They have the potential to undergo further technological developments in future studies.

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Lactate as a Biomarker for Sleep

Abstract: These findings indicate that extracellular lactate concentration is a reliable sleep/wake biomarker and can be used independently of the EEG signal.

Cited by 84 publications

References 50 publications

Stilbene Glucoside, a Putative Sleep Promoting Constituent from <i>Polygonum multiflorum</i> Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

Stilbene Glucoside, a Putative Sleep Promoting Constituent from <i>Polygonum multiflorum</i> Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography

Microelectrode Biosensors for in vivo Analysis of Brain Interstitial Fluid

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