Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study

Russo, Antonio; Pisaturo, Mariantonietta; Luca, Ilaria De; Schettino, Ferdinando; Maggi, Paolo; Numis, Fabio Giuliano; Gentile, Ivan; Sangiovanni, Vincenzo; Rossomando, Anna Maria; Gentile, Valeria; Calabria, Giosuele; Rescigno, Caroliona; Megna, Angelo Salomone; Masullo, Alfonso; Manzillo, Elio; Russo, Grazia; Parrella, Roberto; Dell’Aquila, Giuseppina; Gambardella, Michele; Ponticiello, Antonio; Reginelli, Alfonso; Coppola, Nicola

doi:10.1016/j.jiph.2022.12.009

Cited by 4 publications

(2 citation statements)

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“…The literature highlights that PaO2/FiO2 ratio at admission is a predictor of worse CT score in COVID-19 patients and a negative outcome of the disease [ 17 ]. Considering the lower PaO2/FiO2 ratio in patients with obesity compared with patients without, we underline that obesity is associated with impaired pulmonary function, with decreased expiratory reserve volume, functional capacity, and respiratory system compliance.…”

Section: Discussionmentioning

confidence: 99%

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Obesity as a Risk Factor of Severe Outcome of COVID-19: A Pair-Matched 1:2 Case–Control Study

Russo

Pisaturo

Zollo

et al. 2023

JCM

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Background and aim. The nature of the association between obesity and poor prognosis of COVID-19 without the evaluation of other co-pathologies associated has not yet been clearly evaluated. The aim of the present pair-matched case–control study was to investigate the outcome of patients with SARS-CoV-2 infection in obese and non-obese patients matched considering gender, age, number of comorbidities, and Charlson Comorbidity Index. Methods. All the adults hospitalized for SARS-CoV-2 infection and with BMI ≥ 30 kg/m2 were included (Cases). For each Case, two patients with BMI < 30 kg/m2 pair matched for gender, age (±5 years), number of comorbidities (excluding obesity), and Charlson Comorbidity Index (±1) were enrolled (Controls). Results. Of the 1282 patients with SARS-CoV-2 infection followed during the study period, 141 patients with obesity and 282 patients without were enrolled in the case and control groups, respectively. Considering matching variables, there was no statistical difference between the two groups. Patients in the Control group developed more frequently a mild–moderate disease (67% vs. 46.1%, respectively), whereas obese patients were more prone to need intensive care treatment (41.8% vs. 26.6%, respectively; p = 0.001). Moreover, the prevalence of death during hospitalization was higher in the Case group than in the Control group (12.1% vs. 6.4%, p = 0.046). Discussion. We confirmed an association between obesity and severe outcome of patients with COVID-19, also considering other factors associated with a severe outcome of COVID-19. Thus, in the case of SARS-CoV-2 infection, the subjects with BMI ≥ 30 kg/m2 should be evaluated for early antiviral treatment to avoid the development of a severe course.

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Section: Discussionmentioning

confidence: 99%

“…No study protocol or guidelines regarding the criteria of hospitalization were shared among the centers involved in the study, and the patients were hospitalized following the decision of physicians of each center. The details of the Campania COVID-19 cohort (CoViCamp cohort) were reported in previous studies [ 4 , 5 , 16 , 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%