Lactate dehydrogenase as a predictor of kidney involvement in patients with sickle cell anemia

Gurkan, Sevgi; Scarponi, Kyla J.; Hotchkiss, Hilary; Savage, Beth; Drachtman, Richard A.

doi:10.1007/s00467-010-1560-8

Cited by 58 publications

(46 citation statements)

References 28 publications

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“…Literature on this issue is divergent where some studies have found a relationship [45,46] and others have not [47,48]. Further studies are needed to continue understanding the pathophysiological mechanisms underlying renal dysfunction in SCD.…”

Section: Discussionmentioning

confidence: 92%

Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Asnani

Reid

2015

Blood Cells, Molecules, and Diseases

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Section: Discussionmentioning

confidence: 92%

Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Asnani

Reid

2015

Blood Cells, Molecules, and Diseases

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“…In children with SCA, significant associations have been found between proteinuria and the hemolysis markers of low hemoglobin (Hb) and high lactate dehydrogenase (LDH). 5,13 Similar studies in adults, however, have not replicated this finding, although an association between low hemoglobin levels and hyperfiltration have been reported. [14][15] More recently, Maier-Redelsperger et al utilized a marker of red cell survival derived from mature red blood cell hemoglobin (RBC Hb) and reticulocyte hemoglobin (RET Hb), and showed that the log (RBC Hb/RET Hb) was highly correlated with LDH, bilirubin and albuminuria.…”

Section: Introductionmentioning

confidence: 92%

Association between hemolysis and albuminuria in adults with sickle cell anemia

Day

Drašar²,

Fulford³

et al. 2011

Haematologica

104

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We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. While significant associations were found in HbSS and HbSb 0 (sickle cell anemia) patients with and without controlling for covariates between hemolytic markers and albuminuria, the associations were not significant in patients with HbSC. Estimated glomerular filtration rate, a marker of renal function, correlated significantly with reticulocyte count and bilirubin. Alpha thalassemia, present in 34% of the sickle cell anaemia patients, had a protective effect against albuminuria in this group. Altogether, the incidence of hyperfiltration was 71% and microalbuminuria 37%, making nephropathy a common complication of sickle cell anemia. Haematologica 2012;97(2):201-205. doi:10.3324/haematol.2011 This is an open-access paper. ABSTRACTexcluded from the study group if they had a history of diabetes mellitus, HIV infection, malignancy or another cause of chronic kidney disease (CKD) or if they were on a blood transfusion program. Seventeen patients were on ACE (angiotensin converting enzyme) inhibitor or ARB (angiotensin II receptor blocker) therapy; these patients were also excluded from the study. Since 2006, urinary albumin/creatinine ratio (ACR) has been a routine measurement for patients attending the specialist clinic. All patients were routinely genotyped for α thalassemia using a PCR-based methodology on DNA extracted from peripheral blood.17

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“…Univariate and multivariate analyses showed a significant correlation between LDH level and microalbuminuria and proteinuria. 7 Kato et al reported an association between hemolysis and clinical subphenotypes of SCD, including pulmonary hypertension (PH), but the diagnosis of hemolysis was based on LDH levels. 8 Conversely, Ataga et al reported a significant correlation between PH and microalbuminuria, but no correlation with parameters of hemolysis.…”

Section: To the Editormentioning

confidence: 99%

Lactate dehydrogenase and hemolysis in sickle cell disease

Ballas

2013

Blood

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LFA-1 is strictly required for neutrophil migration at the initiation phase of K/BxN arthritis, 3,4 other pathways can often compensate for ␤2 integrin deficiency in the context of bacterial infection. 5,6 Because we found that Ly6G ligation attenuated ␤2 integrin-dependent migration, but not ␤2 integrin-independent migration, 2 it is not clear that an effect would have been expected in the Staphylococcus aureus cellulitis model used by Drs Yipp and Kubes.However, we recognize that divergent dependence on ␤2 integrins cannot be the whole story. The Kubes laboratory has employed conjugated anti-Gr-1 as an in vivo tool in several important studies using models of sterile inflammation in which ␤2 integrins play a demonstrable role. 6,7 Further investigation will be required to determine the relevant differences between these experimental systems and those used in our work.We therefore interpret the findings of Drs Yipp and Kubes as complementary to, rather than in conflict with, our own. Together, these studies raise new and interesting questions. What are the conditions under which Ly6G-binding ligation alters migration? What is the role of Ly6G in the normal course of neutrophil physiology? What does this role of Ly6G tell us about human neutrophil biology? We look forward to working with the Kubes laboratory and others to answer these important questions.

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Lactate dehydrogenase as a predictor of kidney involvement in patients with sickle cell anemia

Cited by 58 publications

References 28 publications

Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Cystatin C: A useful marker of glomerulopathy in sickle cell disease?

Association between hemolysis and albuminuria in adults with sickle cell anemia

Lactate dehydrogenase and hemolysis in sickle cell disease

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