Lactate versus acetate buffered intravenous crystalloid solutions: a scoping review

Crystalloid and Colloid Compositions and Their Impact

“…The infusion of lactate has been reported to have systemic effects including immune, coagulation and hemodynamic changes. Although there are a growing number of comparison studies between lactate and acetate containing fluids, the results are inconsistent, and more research is needed to fully understand these issues (76).…”

Acetate‐ versus lactate‐buffered crystalloid solutions: A systematic review with meta‐analysis and trial sequential analysis

“…We exclusively evaluated patient‐important outcome measures. Interestingly, a previous scoping review comparing acetate‐ versus lactate‐buffered solutions regardless of study design or type of outcome found that less than 25% of studies reported patient‐centered outcome measures 16 . Importantly, trials reporting surrogate outcome measures are more likely to produce falsely inflated estimates and are at increased risk of false‐positive findings 52,53 …”

“…Interestingly, a previous scoping review comparing acetate-versus lactate-buffered solutions regardless of study design or type of outcome found that less than 25% of studies reported patient-centered outcome measures. 16 Importantly, trials reporting surrogate outcome measures are more likely to produce falsely inflated estimates and are at increased risk of false-positive findings. 52,53 Considering the vast use of buffered crystalloid solutions in clinical practice, the lack of data comparing their individual effects on patientimportant outcomes is surprising.…”

“…The effects of these alternative buffers in clinical practice are poorly described, and the adverse events differ between the solutions. 16 Current clinical practice guidelines do not distinguish between the different types of buffered solutions depending on their buffering anion. 6,7 As buffered crystalloid solutions have varying compositions, considering them as a single class of fluid could potentially cause for misinterpretation of different effects between the different solutions thus underlining the importance of this research question.…”

“…The effects of these alternative buffers in clinical practice are poorly described, and the adverse events differ between the solutions 16 . Current clinical practice guidelines do not distinguish between the different types of buffered solutions depending on their buffering anion 6,7 .…”