Lactic acid purification by reactive distillation system using design of experiments

Komesu, Andrea; Martinez, Patrícia Fazzio Martins; Lunelli, Betânia Hoss; Filho, Rubens Maciel; Maciel, Maria Regina Wolf

doi:10.1016/j.cep.2015.05.005

Cited by 38 publications

(17 citation statements)

References 16 publications

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“…Thus far, it was not possible to develop a statistical model for these responses. This result was not expected, once in the previous works it was observed a high influence of all these parameters in the residue stream responses (Komesu et al 2013(Komesu et al , 2014ba, 2015a;Oliveira et al 2017).…”

Section: Residue Stream Analysismentioning

confidence: 56%

“…The main difference between these studies was the feed composition stream used in the separation process. In previous studies (Komesu et al 2013(Komesu et al , 2014a(Komesu et al ,b, 2015a, the authors' research group has studied the LA concentration using a fermentation broth composed by 5% (w/w) of LA containing a minimal amount of residual sugar in the HSPE. In this work, the fermentation broth used had high LA (approximately 100 g/L) and TRS (approximately 85 g/L) concentrations.…”

Section: General Analysismentioning

confidence: 99%

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Evaluation of Hybrid Short Path Evaporation to Concentrate Lactic Acid and Sugars from Fermentation

et al. 2018

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Lactic acid is an important organic compound that finds various applications in the chemical, pharmaceutical, food, and medical industries. Many of these applications require lactic acid with high purity. Hybrid short path evaporation (HSPE) is a separation process well studied in the petrochemical sector that is mainly used to obtain compounds with high purity. It is also a process offering small residence time, low pressure, and environmentally friendliness. The concentration process of lactic acid was studied by using HSPE in the presence of high total reducing sugar content remaining from sugarcane molasses fermentation. In this work, the influence of operational conditions, such as evaporator temperature (86.4 °C to 153.6 °C), internal condenser temperature (7.95 °C to 18 °C), and feed flow rate (8.27 to 21.7 mL/min), on lactic acid concentration and mass percentages were evaluated. The results showed that all variables influenced the process. Mathematical models were developed for the mass percentage and concentration of the total reducing sugar in the distilled stream and for the mass percentage at residue stream. Under the best operational conditions, the concentration of lactic acid (≈ 247.7 g/L) was 2.5 times higher than the initial fermentation broth (≈ 100.1 g/L).

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Section: Residue Stream Analysismentioning

confidence: 56%

Section: General Analysismentioning

confidence: 99%

Evaluation of Hybrid Short Path Evaporation to Concentrate Lactic Acid and Sugars from Fermentation

et al. 2018

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“…For conventional columns, reflux ratio has an important effect on removal of the light product methanol from the top of column, whereas the reflux ratio plays a significant role in the removing of lactic acid from the bottom of the column in the case of inverted column operation. In order to minimize the total capital and operating cost, the purification of lactic acid from fermentation broth by reactive distillation using design of experiments was evaluated . This purification process presents great ability to obtain high yield of ethyl lactate (∼100%) and to enhance lactic acid concentration from the initial concentration by three times.…”

Section: Approach To Problem Solvingmentioning

confidence: 99%

Potential and assessment of lactic acid production and isolation - a review

Jantasee

Kienberger

Mungma

et al. 2017

J. Chem. Technol. Biotechnol

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The majority of commodity plastics is made from petroleum-based chemicals. Lactic acid serves as a monomer for the production of the biodegradable polymer polylactic acid (PLA). This paper provides a review on the state of the art production and isolation process for lactic acid. Problems in production and isolation have been identified, the relevant results in optimized production are presented in the first part of the paper. In the second part, a decision matrix is used as a guideline for the discussion on the state of research in the isolation and purification of lactic acid. Mechanical unit operations, mass transfer unit operations, reactive separation techniques, and process combinations are reported in the literature. At the end, an economic evaluation of isolation processes such as conventional precipitation, reactive membrane separation, and reactive distillation are presented.

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“…The injector and the detector temperatures were maintained at 240 °C and 250 °C, respectively. In each run, an injection volume of 1 μL was used [28].…”

Section: Methodsmentioning

confidence: 99%

Separation of Lactic Acid from Diluted Solution by Hybrid Short Path Evaporation and Reactive Distillation

Komesu¹,

Oliveira²,

Maciel³

et al. 2016

JCCE

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Lactic acid purification by reactive distillation system using design of experiments

Cited by 38 publications

References 16 publications

Evaluation of Hybrid Short Path Evaporation to Concentrate Lactic Acid and Sugars from Fermentation

Evaluation of Hybrid Short Path Evaporation to Concentrate Lactic Acid and Sugars from Fermentation

Potential and assessment of lactic acid production and isolation - a review

Separation of Lactic Acid from Diluted Solution by Hybrid Short Path Evaporation and Reactive Distillation

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