Lactobacilli Infection Case Reports in the Last Three Years and Safety Implications

Rossi, Franca; Amadoro, Carmela; Colavita, Giampaolo

doi:10.20944/preprints202202.0248.v1

Cited by 9 publications

(1 citation statement)

References 45 publications

(114 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to establish the appropriate target population. Individuals with pre-established health conditions that lead to compromised immune systems should not be eligible for use of probiotics in conjunction with antibiotic therapy (Rossi et al 2022).Resistance to adverse effects caused by gastrointestinal transit is also a criterion evaluated when choosing potentially probiotic strains, especially when the goal is to select probiotics with action on intestinal disorders. When other features and application forms are explored, as in the case of adjuvant action in the treatment of dysbiosis of the vaginal tract, this criterion is not so necessary (Chenoll et al 2019).…”

Section: Nucleic Acid Synthesis Inhibitorsmentioning

confidence: 99%

In vitro selection and characterization of probiotic properties in eight lactobacillus strains isolated from cocoa fermentation

Almeida

Pessoa

Melgaço

et al. 2022

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Traditionally, probiotic microorganisms are isolated from human and animal intestinal microbiota. However, the demand for diversification of biofunctional products has driven the search for new sources of probiotic candidates, such as fermented foods and vegetables. The present study found that strains isolated from the fermentation of fine cocoa from southern Bahia have biotechnological potential for use as a probiotic, since they showed capacity for self-aggregation and co-aggregation, antimicrobial activity against intestinal pathogens and resistance to gastrointestinal transits. Scores of importance for each property were established in order to more accurately assess the probiotic potential of the strains. The tests carried out contemplate the criteria previously established for the selection of probiotic candidates.

show abstract

Section: Nucleic Acid Synthesis Inhibitorsmentioning

confidence: 99%

In vitro selection and characterization of probiotic properties in eight lactobacillus strains isolated from cocoa fermentation

Almeida

Pessoa

Melgaço

et al. 2022

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

show abstract

Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements

et al. 2022

View full text Add to dashboard Cite

In this study, we screened eight commercially available brands of Lactobacillus-containing probiotic preparations and dietary supplements for resistance towards commonly administered antibiotics of different classes. According to disc diffusion results, most of the isolates were resistant to vancomycin and susceptible to penicillin-type antibiotics (ampicillin and amoxicillin), carbapenems (imipenem, meropenem, and ertapenem), and inhibitors of protein synthesis (chloramphenicol, erythromycin, tetracycline, clarithromycin, and linezolid). However, based on minimum inhibitory concentration (MIC) values, six strains were reconsidered as resistant to tetracycline. All tested lactobacilli were resistant towards amikacin, ciprofloxacin, and norfloxacin. Resistance to cephalosporins was highly variable and decreased in the following order: ceftazidime/cefepime, ceftriaxone, cefotaxime, cefazolin, and cefoperazone. PCR screening for antibiotic resistance determinants in probiotic lactobacilli revealed a wide occurrence of vancomycin resistance gene vanX, ciprofloxacin resistance gene parC, and extended-spectrum β-lactamase gene blaTEM. We also detected the tetK gene for tetracycline resistance in one isolate. Additionally, we identified discrepancies between the claims of the manufacturers and the identified species composition, as well as the enumerated amount of viable bacteria, for several products. The results of this study raise concerns about the safety of lactobacilli for human consumption as probiotics, as they may act as reservoirs of transferable antibiotic resistance genes.

show abstract

Infective Endocarditis by Lactobacillus Species—A Narrative Review

Ioannou,

Ziogou,

Giannakodimos

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Bacteria of the genus Lactobacillus are microaerophilic or aerotolerant anaerobic Gram-positive non-spore-forming rods. They are considered essential members of the human gut microbiome; however, recent studies have revealed that these microorganisms are less predominant in the gut microbiome than initially thought. Lactobacillus spp. is mainly known for its use as a probiotic in foods and supplements to prevent and treat specific issues such as infectious diseases, irritable bowel syndrome, and diabetes mellitus. However, Lactobacillus spp. may occasionally cause infections such as bacteremia or infective endocarditis (IE). The present study aimed to review all cases of IE by Lactobacillus spp. and describe the epidemiology, microbiology, clinical characteristics, treatment, and outcomes of this infection by collecting relevant data from studies existing in Pubmed and Scopus until 28 September 2023. A total of 77 studies containing data for 82 patients were included. The median age was 56 years, and 69.6% were male. A prosthetic valve was present in 16% of patients, and 17.3% had previously been on probiotics. The aortic valve was the most commonly involved intracardiac site, followed by the mitral valve. Fever, embolic phenomena, sepsis, and heart failure were the most common clinical presentations. Aminoglycosides and penicillin were the most commonly used antimicrobials for definitive treatment. Surgery was performed in 53.7% of patients. Overall mortality was 17.1%. IE in prosthetic valves and presentation with shock were independently associated with overall mortality.

show abstract

Lactobacilli Infection Case Reports in the Last Three Years and Safety Implications

Cited by 9 publications

References 45 publications

In vitro selection and characterization of probiotic properties in eight lactobacillus strains isolated from cocoa fermentation

In vitro selection and characterization of probiotic properties in eight lactobacillus strains isolated from cocoa fermentation

Alarming Antibiotic Resistance of Lactobacilli Isolated from Probiotic Preparations and Dietary Supplements

Infective Endocarditis by Lactobacillus Species—A Narrative Review

Contact Info

Product

Resources

About