Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model

Núñez, Ivanna Novotny; Galdeano, Carolina Maldonado; LeBlanc, Alejandra de Moreno de; Perdigón, Gabriela

doi:10.1016/j.nut.2015.02.006

Cited by 46 publications

(35 citation statements)

References 37 publications

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“…This decreased IL-6 could be confirmed by the present results in regard to the micro assessment of colitis, as well as histopathological changes revealed less macrophages accumulation and immune cell infiltration in colon wall of treated rats, consequently reduced the inflammatory reactions and production of IL-6 (Novotny et al, 2015).…”

Section: Resultssupporting

confidence: 87%

Effect of Lactobacillus acidophilus on some Physiological and Immunological Aspects in Experimentally Induced Colitis in Rats

qayim¹,

Bakhit²

2016

Adv. Anim. Vet. Sci.

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Section: Resultssupporting

confidence: 87%

Effect of Lactobacillus acidophilus on some Physiological and Immunological Aspects in Experimentally Induced Colitis in Rats

qayim¹,

Bakhit²

2016

Adv. Anim. Vet. Sci.

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“…Interestingly, modulating both GSK3β and STAT3 has been shown to improve photoreceptor survival [26]. Several studies have shown that various dietary supplements, such as supplementation with probiotic bacteria given to mice fed a high-fat diet [27, 28], can significantly regulate cytokines and proinflammatory factors, and the grape diet may follow a similar mechanism of action. Therefore, future work will investigate the mechanism of action of the grape diet by assessing levels of oxidative stress, pro-survival molecules and inflammation in the retina.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of a grape-supplemented diet in a mouse model of retinal degeneration

et al. 2016

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Objective Retinal degenerations are a class of devastating blinding diseases that are characterized by photoreceptor dysfunction and death. In this study, we tested whether grape consumption, in the form of freeze-dried grape powder (FDGP), improves photoreceptor survival in a mouse model of retinal degeneration. Methods Retinal degeneration was induced in mice by acute oxidative stress using subretinal injection of paraquat and comparisons were to equivalent volumes of injected saline. The grape-supplemented diet was made by formulating base mouse chow with FDGP, corresponding to 3 daily human servings of grapes, and a control diet was formulated with equivalent sugar composition as FDGP (0.68% glucose/0.68% fructose mixture). Mice were placed on the diets at weaning for 5 weeks prior to oxidative stress injury until analysis at 2 weeks post-injection. Retinal function was measured using electroretinography, thickness of the photoreceptor layer was measured using optical coherence tomography, and rows of photoreceptor nuclei were counted on histological sections. Results In mice fed the control diet, oxidative stress significantly reduced photoreceptor layer thickness and photoreceptor numbers. In contrast, retina thickness and photoreceptor numbers were not reduced by oxidative stress in mice on the grape-supplemented diet, indicating significantly higher photoreceptor survival after injury than mice on the control diet. Furthermore, mice on the grape diet showed preservation of retina function after oxidative stress injury compared with mice on the control diet. Conclusions A diet supplemented with grapes rescued retinal structure and function in an oxidative stress-induced mouse model of retinal degeneration, which demonstrates the beneficial effect of grapes on photoreceptors.

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“…In a previous in vitro study, we showed that L. helveticus SBT2171 was able inhibit the production of inflammatory cytokines, including IL-6, in primary murine immune cells (Yamashita et al, 2014). Other studies have also reported the suppressive effects of LAB on inflammatory cytokine production in vitro and in vivo (Griet et al, 2014; Novotny et al, 2015). Based on these findings, the reduction in the IL-6 level by L. helveticus SBT2171 might closely correlate with CIA alleviation.…”

Section: Discussionmentioning

confidence: 94%

Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

et al. 2017

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We recently reported that the intraperitoneal inoculation of Lactobacillus helveticus SBT2171 inhibited the development of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). In the present study, we evaluated the effect of the oral administration of L. helveticus SBT2171 on CIA development and on the regulation of antigen-specific antibody production and inflammatory immune cells, which have been implicated in the development of RA. Both oral administration and intraperitoneal inoculation of L. helveticus SBT2171 reduced joint swelling, body weight loss, and the serum level of bovine type II collagen (CII)-specific antibodies in the CIA mouse model. The intraperitoneal inoculation also decreased the arthritis incidence, joint damage, and serum level of interleukin (IL)-6. In addition, the numbers of total immune cells, total B cells, germinal center B cells, and CD4+ T cells in the draining lymph nodes were decreased following intraperitoneal inoculation of L. helveticus SBT2171. These findings demonstrate the ability of L. helveticus SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.

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Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model

Cited by 46 publications

References 37 publications

Effect of Lactobacillus acidophilus on some Physiological and Immunological Aspects in Experimentally Induced Colitis in Rats

Effect of Lactobacillus acidophilus on some Physiological and Immunological Aspects in Experimentally Induced Colitis in Rats

Protective effects of a grape-supplemented diet in a mouse model of retinal degeneration

Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

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