Lactoferrin Efficacy versus Ferrous Sulfate in Curing Iron Disorders in Pregnant and Non-Pregnant Women

Paesano, Rosalba; Berlutti, Francesca; Pietropaoli, Miriam; Goolsbee, W; Pacifici, E.; Valenti, Piera

doi:10.1177/039463201002300220

Cited by 59 publications

(81 citation statements)

References 32 publications

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“…Moreover, the exogenous bovine form, administered for treating iron deficiency anemia, has been reported to decrease IL-6 concentration in the maternal serum [7]. …”

Section: Discussionmentioning

confidence: 99%

“…In this regard, we have shown that ampicillin is able to decrease Il-6 release by WHISH cells, a human amnion-derived cell line, as well as the AF cytokine concentration in women undergoing second trimester amniocentesis [6]. In the present study we focused on lactoferrin (LF), an 80-kDa iron-binding glycoprotein of the transferrin family provided with anti-inflammatory and antimicrobial properties, which is able to decrease IL-6 in several experimental conditions [7]. LF is physiologically present in AF [8,9], and it is frequently administered to pregnant women for treating iron deficiency anemia [10].…”

Section: Introductionmentioning

confidence: 99%

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Vaginal Lactoferrin Administration before Genetic Amniocentesis Decreases Amniotic Interleukin-6 Levels

Vesce

Giugliano

Bignardi

et al. 2014

Gynecol Obstet Invest

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Aim: To verify the eventual efficacy of lactoferrin (LF), an iron-binding glycoprotein, to decrease the amniotic concentration of interleukin-6 (IL-6). Methods: We prospectively enrolled 60 Caucasian patients at the 16th week of their singleton physiological gestation. A vaginal compound containing 300 mg of LF was administered randomly 4 or 12 h prior to amniocentesis, as to obtain 3 groups: A, 20 untreated patients; B, 20 treated 4 h before amniocentesis; C, 20 treated 12 h before amniocentesis. Results: A normal karyotype was registered in all cases. The comparison of the distribution of IL-6 among the 3 groups showed a highly significant difference (p = 0.001). The difference between mean values of group B and both groups C and A was shown to be highly significant (p = 0.006 and p = 0.03, respectively). In contrast, there was no significant difference between mean values of groups A and C. Conclusion: Vaginal LF administration decreases amniotic IL-6 concentration. We therefore suggest that the glycoprotein may exert a protective role against ominous pregnancy complications linked to an increased level of the cytokine, such as abortion secondary to amniocentesis.

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“…Moreover, the exogenous bovine form, administered for treating iron deficiency anemia, has been reported to decrease IL-6 concentration in the maternal serum [7]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vaginal Lactoferrin Administration before Genetic Amniocentesis Decreases Amniotic Interleukin-6 Levels

Vesce

Giugliano

Bignardi

et al. 2014

Gynecol Obstet Invest

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“…In line with these data, Paesano et al (35,36) found bovine lactoferrin established iron homeostasis by modulating serum IL-6 and pro-hepcidin synthesis, whereas ferrous sulfate increased IL-6 and failed to increase hematological parameters and prohepcidin. Also, Lee et al (37) detected high ferritin and hepcidin concentrations and considered these high levels as a consequence of inflammation because IL-6 concentrations at delivery were 1.6-fold higher than mid-gestation levels with a positive association between IL-6 and both hepcidin and ferritin.…”

Section: Discussion:-mentioning

confidence: 75%

Gestational Iron Deficiency Anemia Is Not Simply a Consequence of Iron Deficiency: An Observational Study for Cofounders.

HeshamMAboRagab¹,

EhabBarakat²,

OmmniaAbdulla³

2018

IJAR

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Objectives:To evaluate serum levels of vitamin D (VD), hepcidin, interleukin (IL)-6 and iron indices in pregnant women Patients & Methods: 88 pregnant women fulfilling the inclusion criteria underwent full clinical examination and gave blood samples for determination of hemoglobin concentration (Hb. Conc.), and ELISA estimation of serum 25-hydroxy VD (25OH-VD), ferritin concentration (SFC), hepcidin and IL-6 at the 6 th wk gestational age (Booking time) and underwent re-determination of Hb. Conc. at start of the 3 rd trimester and Hb. Deficit was calculated. Study outcome included determination of the frequency of iron deficiency (ID), iron deficiency anemia (IDA) and VD deficiency (VDD) and evaluation of the relations between these parameters. Results: At booking time, 17 women were anemic (Hb. Conc. <11 gm/dl), while 14 women had SFC<15 ng/ml, for a frequency of anemia, ID and IDA of 19.3%, 15.9% and 11.4%, respectively. At the 3 rd trimester, 35 women had Hb. Conc. <11 gm/dl, thus the frequency of IDA was doubled during pregnancy with significantly (p=0.0029) higher frequency of anemic women and significantly (p=0.0007) lower mean Hb. Conc. compared to booking time with a median decrease of Hb. deficit by 4.96% (95% ICR: -7 to -3.23). At booking time, 17 women had insufficient VD levels and 64 women had VDD. At booking Hb. Conc. and deficit was significantly correlated with serum FC, 25OH-VD, hepcidin and IL-6. Serum 25OH-VD level showed significant correlation with SFC, hepcidin and IL-6 levels, and serum hepcidin levels was significantly correlated with serum FC and IL-6. Regression analysis defined at booking high serum hepcidin and IL-6 as significant negative, while high serum 25OH-VD level as significant positive predictor for oncoming 3 rd trimester Hb. conc. For prediction of the extent of Hb. deficit, at booking high serum 25OH-VD was negative (β=-0.307, p=0.004), while serum IL-6 level was positive (β=0.235, p=0.026) significant predictors for high deficit. Conclusion: Gestational IDA is a progressive condition weakly responding to iron supplemental therapy. IDA is a multi-factorial condition strongly associated with VDD, disturbed immune milieu and deregulated iron homeostasis. VDD plays a crucial role in pathogenesis of ADI.

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“…The other uses of lactoferrin in field of perinatology includes its role in retinopathy of prematurity, prevention of preterm labor and in treatment of iron deficiency anaemia of pregnancy [39][40][41][42]. …”

Section: Necrotizing Enterocolitis (Nec)mentioning

confidence: 99%

Lactoferrin and Its Role in Neonatology: A Review Article

Sharma¹

2015

JPNC

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Lactoferrin (LF) is a glycoprotein, which is present in milk of mammals. It has been proven to plays a very important role in innate immune host defences. It is well known that Neonatal sepsis and necrotizing enterocolitis (NEC) are responsible for significant morbidity and mortality in the new-born, especially in VLBW (1500 grams at birth) infants. The ill effects of sepsis and NEC persist in spite of appropriate and effective antibiotic therapy and have been associated with poor long term outcome. In the few recent trials which have been conducted around the globe, in field of neonatology, role of LF in prevention of neonatal sepsis and NEC has been strengthened. Furthermore many trials are underway and only future may provide a definite answer of LF role in sepsis and NEC. This review article has been written to through some light on the recent work that has already been done, to strengthen the role of LF in neonatal sepsis and the work that is still under process.

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Lactoferrin Efficacy versus Ferrous Sulfate in Curing Iron Disorders in Pregnant and Non-Pregnant Women

Cited by 59 publications

References 32 publications

Vaginal Lactoferrin Administration before Genetic Amniocentesis Decreases Amniotic Interleukin-6 Levels

Vaginal Lactoferrin Administration before Genetic Amniocentesis Decreases Amniotic Interleukin-6 Levels

Gestational Iron Deficiency Anemia Is Not Simply a Consequence of Iron Deficiency: An Observational Study for Cofounders.

Lactoferrin and Its Role in Neonatology: A Review Article

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