Lactoferrin: Major Physiological Functions and Applications

Hao, Liyuan; Shan, Qiang; Wei, Jingya; Ma, Fengtao; Sun, Peng

doi:10.2174/1389203719666180514150921

Cited by 129 publications

(102 citation statements)

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“…Its amino acid sequence relationships place it in the wider transferrin family (Baker and Baker, 2005). It is known that lactoferrin regulates the quantity of iron absorbed in the intestine via its role in iron transport, and it can chelate iron, directly or indirectly (Hao et al, 2019). Lactoferrin has been used as an adjuvant therapy for some intestinal diseases and is now used in nutraceutical supplemented infant formula and other food products (Hao et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that lactoferrin regulates the quantity of iron absorbed in the intestine via its role in iron transport, and it can chelate iron, directly or indirectly (Hao et al, 2019). Lactoferrin has been used as an adjuvant therapy for some intestinal diseases and is now used in nutraceutical supplemented infant formula and other food products (Hao et al, 2019). Lactoferrin also has other numerous biological roles, such as the modulation of immune responses and anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities (Hao et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Lactoferrin has been used as an adjuvant therapy for some intestinal diseases and is now used in nutraceutical supplemented infant formula and other food products (Hao et al, 2019). Lactoferrin also has other numerous biological roles, such as the modulation of immune responses and anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities (Hao et al, 2019). The average of the body weight before and after administration.…”

Section: Discussionmentioning

confidence: 99%

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Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

et al. 2020

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Background: Lactoferrin, a type of glycoprotein, is contained in exocrine fluids such as tears, breast milk, sweat, and saliva, and is known to have anti-microbial, antioxidant, and anti-cancer effects. In the ophthalmological field, topical administration of lactoferrin has been reported to have a therapeutic effect in a murine dry eye model. Hypoxia-inducible factor (HIF) regulates various gene expressions under hypoxia, including vascular endothelial growth factor (VEGF), and is considered as an alternative target for neovascular ocular diseases such as age-related macular degeneration (AMD). We previously screened natural products and identified lactoferrin as a novel HIF inhibitor. In this study, we confirmed that lactoferrin has an HIF inhibitory effect and a therapeutic effect in a murine model of neovascular AMD.Methods: HIF inhibitory effects of lactoferrin were evaluated using a luciferase assay and western blotting in vitro. The quantified volume of choroidal neovascularization (CNV) induced by laser irradiation was compared with oral lactoferrin administration or conditional tissue specific Hif1a knockout mice.Results: Lactoferrin administration showed a significant HIF inhibitory effect in the retinal neuronal cells. Oral administration of lactoferrin or conditional Hif1a gene deletion significantly reduced CNV volume compared to controls.Conclusions: Lactoferrin has a therapeutic effect in a laser CNV model by suppressing the retinal HIF activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

et al. 2020

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“…It also improves the health status of Alzheimer's disease patients. [13][14][15] Glyco-macropeptide, a peptide of kappa-casein, exhibits antithrombotic and anti-bacterial potential. α-lactalbumin also reveals antitumoral, antiviral, and antistress perspectives.…”

Section: Anti-microbial Proteinsmentioning

confidence: 99%

Lactoferrin (LF): a natural antimicrobial protein

Niaz

Saeed

Ahmed

et al. 2019

International Journal of Food Properties

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Improved awareness regarding diet and health linkages has motivated researchers to give more attention to the health perspectives of individual foods. During the previous two decades, the global dairy industry diverted its interest from simple processing of commodities to the value addition. A significant income is being earned in the dairy industry from specialty proteins. Pakistan ranked 3 rd in milk production worldwide and different milking animals e.g. cow, buffalo, goat and camel should be studied for their potential for generating new health-promoting diets and nutraceuticals foods. Bioactive proteins and peptides from having abundant applications including an antimicrobial food additive, dietary supplements, functional foods and nutraceuticals. Proteins from milk have a balanced composition of amino acids promising novel functional products. These also enhance the consistency and sensorial characteristics of various dairy products. Amongst, lactoferrin reveal bacteriostatic as well as bactericidal bustle against a variety of microorganisms. It binds iron thus depriving it required for growth like L. monocytogenes, Salmonella spp, Escherichia coli, Bacillus stearothermophilus, Shigella dysenteriae and Bacillus subtilis. Lactoferrin executes as an alternative to antibiotics. It acts as a natural antimicrobial for bio preservation ranging from dairy, meat, seafood, beverages, bakery products, acne care, infant formulas, extending shelf life, ensuring safety and improving health by acting against life-threatening diseases like cancer, hepatitis, respiratory infections, and foodborne diseases in infants, children and adults etc. In the nutshell, the current review discusses the importance and safety perspectives of lactoferrin in the food industry as well as the health sector. ARTICLE HISTORY

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“…Studies have explored the effect of bLF on iron absorption of infant and suggested that formula fortified with bLF could significantly increase hematocrit, serum ferritin (SF), and reticulocyte levels (11)(12)(13)(14)(15)(16). Our previous study (17) also indicated that formula fortified with 38 mg/100 g of bLF positively affected the hemoglobin (Hb) and iron status of infants who were previously exclusively breastfed and suggested that the effects of bLF fortification on iron metabolic homeostasis were mainly exerted through promoting total body iron E-mail: 263662086@qq.com content (TBIC) and iron absorption in intestine.…”

mentioning

confidence: 99%

Dose Effect of Bovine Lactoferrin Fortification on Iron Metabolism of Anemic Infants

Chen

Zhang

Chen

et al. 2020

J Nutr Sci Vitaminol

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To evaluate the effect of iron-fortified formula with different concentrations of bovine lactoferrin (bLF) on improvement of anemic status in term infants who were previously breast-fed. A randomized, controlled, open, and post-market intervention study. A total of 108 infants aged 6-9 mo who were previously breast-fed and weaned were selected. The subjects were divided into three groups with the sequence of outpatient: fortified group 1 (FG1) with a bLF concentration of 38 mg/100 g, FG2 with 76 mg/100 g bLF, FG0 with no bLF. The intervention duration was 3 mo. Weight, height, head circumference and the concentration of hemoglobin (Hb), serum ferritin (SF), serum transferring receptor (sTfR) were measured and sTfR-SF index (TFR-F index) and total body iron content (TBIC) were computed before and after intervention. The primary outcome measures were obtained from 96 infants (35, 33 and 28 for FG0, FG1 and FG2, respectively). After 1 mo of intervention, the changes of Hb level showed no significant difference (p.0.05) among the three groups, however, the Hb level of infants in FG2 were significantly higher than those of infants in the other two groups after 3 mo of intervention (p,0.05). The present data indicated that the formula fortified with 76 mg/100 g bLF positively affected the Hb of anemic infants who were previously breastfed when compared with fortification with 38 mg/100 g bLF and no bLF fortification.

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Lactoferrin: Major Physiological Functions and Applications

Cited by 129 publications

References 0 publications

Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

Lactoferrin (LF): a natural antimicrobial protein

Dose Effect of Bovine Lactoferrin Fortification on Iron Metabolism of Anemic Infants

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