Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)

“…And it was shown that the positively charged Lfs might have attached onto the surface of the PCLs. The comparison of zeta-potential of PCLs and LfPCLs further confirmed the interaction of Lfs with PCLs [63].…”

In vitro screening of nanomedicines through the blood brain barrier: A critical review

“…To this end, a plethora of techniques has been used to verify in vivo the preliminary results obtained with the cellbased assays, namely scintigraphy [324][325][326], near-infrared in vivo imaging [327][328][329][330][331][332][333], ex vivo optical imaging [301,334], confocal microscopy [309,317], chromatographic quantification [307,312,315,335] and pharmacodynamics studies [281,285,336]. In all cases, the consistency between the results from in vitro and in vivo studies was evidenced.…”

“…The main conclusions from the results of the studies presented in Table 7, include the fact that an increase in the size of the nanocarrier yields a decrease in the BBB permeability coefficient [297][298][299][300][301][302][303][304][305] and that nanoparticle surface plays a key role in BBB permeability (in terms of surface coating [306] and surface charge, with enhanced permeability values for cationic charges [302,307,308]). Overall, drug loading onto nanocarriers enhances BBB permeability and this enhancement often follows a timedependent pattern [309][310][311][312][313][314][315].…”

Herbal and polymeric approaches for liver-targeting drug delivery: novel strategies and their significance

“…In general, lactoferrin receptors were used as targeting ligand for delivery of drug to the brain due to the presence of various lactoferrin receptors on blood brain barrier (BBB; Huang et al, 2008;Chen et al, 2010). Recently, it was seen that lactoferrin ligands also have efficiency to bind with the multiple receptors found on the hepatocytes.…”