Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Quan, Guilan; Pan, Xin; Wang, Zhouhua; Wu, Qiaoli; Li, Ge; Dian, Linghui; Bao, Changchun; Wu, Chuanbin

doi:10.1515/nano.12951_2015.22

Cited by 10 publications

(14 citation statements)

References 28 publications

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“…Therefore, the specific endocytotic pathways for Lf-PLS in the different HCC cell lines should be explored. 39 Similar to cellular uptake, cytotoxicity effects of nanoparticles strongly depend on the material, solubility and release of toxic drugs, cell types, and incubation times, etc. 40,41 Previously, empty PLS and Lf-PLS were demonstrated to have good tolerability and low toxicity in target cells (HepG2) and normal cells (ECV 304).…”

Section: Discussionmentioning

confidence: 99%

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Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Wei¹,

Guo

Tu³

et al. 2015

IJN

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Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, a doxorubicin (DOX)-loaded, Lf-modified, polyethylene glycol (PEG)ylated liposome (Lf-PLS) system was developed, and its targeting effect and antitumor efficacy to HCC was also explored. The DOX-loaded Lf-PLS system had spherical or oval vesicles, with mean particle size approximately 100 nm, and had an encapsulation efficiency of 97%. The confocal microscopy and flow cytometry indicated that the cellular uptake of Lf-PLS was significantly higher than that of PEGylated liposome (PLS) in ASGPR-positive cells ( P <0.05) but not in ASGPR-negative cells ( P >0.05). Cytotoxicity assay by MTT demonstrated that DOX-loaded Lf-PLS showed significantly stronger antiproliferative effects on ASGPR-positive HCC cells than did PLS without the Lf modification ( P <0.05). The in vivo antitumor studies on male BALB/c nude mice bearing HepG2 xenografts demonstrated that DOX-loaded Lf-PLS had significantly stronger antitumor efficacy compared with PLS ( P <0.05) and free DOX ( P <0.05). All these results demonstrated that a DOX-loaded Lf-PLS might have great potential application for HCC-targeting therapy.

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Section: Discussionmentioning

confidence: 99%

“…38 To clarify these phenomena, the specific endocytotic pathways for Lf-PLS in different HCC cell lines should be explored. 39 …”

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confidence: 99%

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Wei¹,

Guo

Tu³

et al. 2015

IJN

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“…Outer decoration of MSNs with disulphide linked polymer to achieve the redox responsive release of drug has been done by author Liu R, et al 78 A variety of functional group or moieties can be attached on the surface of MSNs by either of the above mentioned techniques as listed in the Table 2. 11,[79][80][81][82][83][84][85][86][87][88][89][90] Backfilling strategy is another approach used for MSNs fabrication. It is a simple approach to introduce active molecules into the empty pores of mesostructured silica wherein, these empty pores are exposed to the solution or vapour of active molecules and are allowed to diffuse.…”

Section: Post Synthesis Strategymentioning

confidence: 99%

“…10 Mesoporous silica nanoparticle (MSNs) is one of the nano carriers, which are in focus for targeting the tumor cells. 10,11 MSNs based targeted delivery offers a promising tool for increasing the intra tumoral concentration of anticancer drugs and limiting its toxic effects to normal cells as they bind to cell membrane receptors which are over expressed in cancer cells only. This has led to a great research interest towards targeting the drug loaded MSNs into tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Shah¹,

Rajput²

2019

IJPER

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Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications of surface functionalized MSNs in the field of cancer theranostics. It also gives a detailed description of surface decorated MSNs researched upon so far in various types of cancer and the benefits associated with these. Applications: Ease of surface functionalization also offers additional functionalities like cell recognition, absorption of specific biomolecules, improving cell interaction and cellular uptake that significantly modifies the in vitro and in vivo behavior of the drug. Therefore, they have proved to be effective in gene delivery and multi drug resistance cancer treatment. Though, their biocompatibility still remains debatable. Biodegradation of MSNs is quite simple and it is safely excreted through kidneys via silanoic acid formation. Moreover, the USFDA has already approved the silica under the 'GRAS' category which has further made MSNs a thrust area for research in cancer theranostics. Summary: This review summarizes the journey of multifunctional MSNs beginning with its origin, mechanism of formation of mesoporous structure with surface functionalization to till date and recent advances in the arena of cancer targeting.

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“…So some researchers have developed an effective lipid-coated MSN platform for synergistic delivery of Gemcitabine and paclitaxel to human pancreatic cancer [65]. Guilan Quan et al [66] demonstrated that lactosaminated MSNs are promising inorganic carrier systems for asialoglycoprotein receptor-targeted anticancer drug delivery [66]. MSNs are highly interesting for gene delivery applications [67].…”

Section: Other Applicationsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

Jadhav¹

2015

JNMR

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Chemistry, synthesis and functionalization of MSNsWith an abundant availability of various types of surfactants and the development of a deep understanding of sol-gel chemistry, MSNs with different structures have been developed. The size, morphology, pore size and pore structure of MSNs can be rationally designed and the synthesis process can be freely AbstractNanotechnology is a fast-growing area, involving the fabrication and use of nano-sized materials and devices. Nanocomposite materials play a number of important roles in modern science and technology, including pharmaceutical science. Mesoporous materials in particular have a large number of applications. In the past decade, mesoporous silica nanoparticles (MSNs) attracted attention increasingly for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs have significant advantages as drug delivery systems (DDSs) compared with traditional drug nanocarriers. Inorganic mesoporous materials are being used increasingly in pharmaceutical materials research to enhance the dissolution and permeation behavior of drugs that are poorly soluble in water. The benefits of using mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. In this work, we review recent progress in the synthesis and surface functionalization of MSNs for drug delivery applications.

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Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Cited by 10 publications

References 28 publications

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

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Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Cited by 10 publications

References 28 publications

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to&nbsp;hepatocellular carcinoma

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to&nbsp;hepatocellular carcinoma

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

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Resources

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Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma

Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma