Lactose coated ceramic nanoparticles for oral drug delivery

Vengala, Pavani; Dintakurthi, Swetha; Subrahmanyam, C. V. S.

doi:10.1016/j.jopr.2013.06.015

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…In the case of the protein–sugar binding, however, the presentation of the sugar is known to be critical because it determines how the sugars fit within binding pockets on lectins. − This would imply that the rules for sugar–sugar interactions can be translated to other engineered systems having different presentations of sugars. Sugar-coated nanomedicines have been used for dispersing gold nanoparticles and inorganic magnetic nanoparticles in biosensing and theranostic applications, , for targeting labeling probes and gene cargo to specific cells based on their sugar receptor profile, − and for adsorbing and stabilizing bioactive drugs on ceramic cores in aquasome delivery vehicles. − Sugar–sugar adhesion rules could help understand how these sugar-coated vehicles would distribute nonspecifically on the glycosylated surfaces encountered in the host. The composition of N -glycans changes with age and disease .…”

Section: Discussionmentioning

confidence: 99%

Establishing Rules for Self-Adhesion and Aggregation of N-Glycan Sugars Using Virus Glycan Shields

et al. 2020

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The surfaces of cells and pathogens are covered with short polymers of sugars known as glycans. Complex N-glycans have a core of three mannose sugars with distal repeats of N-acetylglucosamine and galactose sugars terminating with sialic acid (SA). Long-range tough and short-range brittle self-adhesions were observed between SA and mannose residues, respectively, in ill-defined artificial monolayers. We investigated if and how these adhesions translate when the residues are presented in N-glycan architecture with SA at the surface and mannose at the core and with other glycan sugars. Two pseudotyped viruses with complex N-glycan shields were brought together in force spectroscopy (FS). At higher ramp rates, slime-like adhesions were observed between the shields, whereas Velcro-like adhesions were observed at lower rates. The higher approach rates compress the virus as a whole, and the self-adhesion between the surface SA is sampled. At the lower ramp rates, however, the complex glycan shield is penetrated and adhesion from the mannose core is accessed. The slime-like and Velcro-like adhesions were lost when SA and mannose were cleaved, respectively. While virus self-adhesion in forced contact was modulated by glycan penetrability, the self-aggregation of the freely diffusing virus was only determined by the surface sugar. Mannose-terminal viruses self-aggregated in solution, and SA-terminal ones required Ca2+ ions to self-aggregate. Viruses with galactose or N-acetylglucosamine surfaces did not self-aggregate, irrespective of whether or not a mannose core was present below the N-acetylglucosamine surface. Well-defined rules appear to govern the self-adhesion and -aggregation of N-glycosylated surfaces, regardless of whether the sugars are presented in an ill-defined monolayer, or N-glycan, or even polymer architecture.

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Section: Discussionmentioning

confidence: 99%

Establishing Rules for Self-Adhesion and Aggregation of N-Glycan Sugars Using Virus Glycan Shields

et al. 2020

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“…At the same time, most homeopathic manufacturers ultimately pour or spray and dry their final liquid potency onto lactose sugar pellets for longerterm storage and administration. Lactose is a known reducing and capping agent for nanoparticle generation from precursor materials as well as carrier for other nanostructures [67,[121][122][123][124][125][126][127].…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle Characterization of Traditional Homeopathically- Manufactured Gelsemium sempervirens Medicines and Placebo Controls

S¹

2015

J Nanomedine Biotherapeutic Discov

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Multiple studies have observed nanostructures in traditionally-manufactured homeopathic medicines. Homeopathy is a 200-year-old system of complementary and alternative medicine used worldwide. The nature of homeopathic medicines has historically stimulated much debate. The present placebo-controlled study extended previous work to characterize nanoparticles (NPs) in homeopathically-prepared Gelsemium sempervirens (GELS), a natural botanical source with previously-documented anxiolytic, analgesic, and anticancer properties. An ethanolic GELS herbal extract was serially diluted and succussed (agitated) in a 95% ethanol-water diluent solvent in glass vials, following Homeopathic Pharmacopoeia of the U.S. guidelines. GELS (VERUM, at homeopathic potencies of 6C, 30C, 200C, each n=3 vials), succussed controls (SUCC-CONT, at homeopathic potencies of 6C, 30C, 200C, each n=3), and one set of unsuccussed solvent control vials also used natural cork (Quercus suber) stoppers (UNSUCC-cork, n=3). A final set of unsuccussed solvent controls used silicone stoppers (UNSUCCsilicone, n=3). Analytical methods included nanoparticle tracking analysis (NTA), zeta potentials, and UV-Visible spectroscopy. NTA revealed >4 x 10 8 nanoparticles per milliliter in all VERUM, SUCC-CONT, and UNSUCC-cork vials, significantly more than the UNSUCC-silicone controls. Particle sizes were polydisperse, significantly larger in the VERUM 30C at 129.8 nanometers versus SUCC-CONT at 6C, 30C, 200C and the UNSUCC-cork controls. Zeta potentials consistent with greater particle stability were significantly most negative in the VERUM GELS 200C (-47.75 mV). Within the UV-vis wavelength range 300-400 nm, the SUCC-CONT 30C exhibited significantly higher, whereas UNSUCC-silicone stopper controls had significantly lower, mean absorbance than all other samples. Taken together, the data suggest that traditional homeopathic methods involving succussions release not only the previously-shown silica from glassware walls, but also Quercus suber materials from natural cork stoppers to stabilize NPs in solution. With verum source material Gelsemium, additional NP size growth and surface stabilization can occur. Further study of homeopathic manufacturing materials and methods and their biological correlates is indicated.

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“…This method involves the addition of 0.19 N diammonium hydrogen phosphate [(NH 4 )2HPO 4 ] solution from a burette in a dropwise manner to calcium nitrate [Ca (NO 3 ) 2 ] solution of 0.32M at a regulated temperature of 50-75°C with uninterrupted stirring alongside maintaining the pH of Ca(NO 3 ) 2 between 8 to 10 with a concentrated solution of ammonia. Three neck round bottom flask can be used as described by Pavani et al each bearing a thermometer, a reflux condenser attached with a CO 2 trap and a charged funnel (27) .…”

Section: Formulation Of the Inorganic Corementioning

confidence: 99%

“…b.// Self-precipitation Vengala et al (27) performed the self-precipitation method for the preparation of the core. In this method, the simulated body fluid (SBF) of pH 7.2 is prepared which contains Sodium Chloride (NaCl), Potassium Chloride (KCl), Magnesium Chloride (MgCl 2 ), Calcium Chloride (CaCl 2 ), sodium hydrogen carbonate (NaHCO 3 ), disodium hydrogen phosphate (Na 2 HPO 4 ), and disodium sulfate (Na 2 SO 4 ).…”

Section: Formulation Of the Inorganic Corementioning

confidence: 99%

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

Rajak,

Islam,

Karmakar

et al. 2023

Ars Pharm

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Introduction: Aquasome is a self-assembled nanoparticulate carrier system with three layers. The system is made up of a polyhydroxy oligomer-coated inner nanocrystalline solid core. Adsorbed on the coated layer are drug molecules or biochemically active compounds. Self-assembly in this sense refers to the independent formation of molecules into organised, long-lasting, and non-covalently bonded patterns.This paper gives an overview of aquasome formation, covering structural properties, formulation methodologies, and the benefits and drawbacks of this novel drug delivery technology. The article primarily addresses the formulation processes used to create self-assembled nanostructures and their various possible applications. Method: Several online databases, including Science Direct, Medline, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to July, 2023. The review paper especially addresses many elements of aquasome formation by various researchers employing methods/modified techniques such as co-precipitation, self-precipitation, sputtering, and and so forth. It also illustrates a variety of fields of therapy in which aquasome has been recognised to have a major influence, such as oxygen and extract carrier. Results: The solid core is responsible for providing structural stability, while the oligomeric coating is crucial for safeguarding against dehydration and stabilising the bioactive molecules. This biodegradable drug delivery vehicle at the nanoscale level exhibits a tendency to accumulate in the liver and muscles. The non-modification of drug adsorption onto the aquasome surface facilitates prompt pharmacological response by allowing unobstructed receptor recognition at the action site. Conclusions: Aquasome, a three-layered self-assembled molecule, is a simple yet new drug delivery system with promising carrier potentials to increase the solubility and bioavailability of poorly soluble drugs. Despite a host of challenges, such as time consumption, sophisticated processes, safety, and expensive research costs, aquasome may emerge as an alternative vesicular carrier in the future.

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Lactose coated ceramic nanoparticles for oral drug delivery

Cited by 11 publications

References 8 publications

Establishing Rules for Self-Adhesion and Aggregation of N-Glycan Sugars Using Virus Glycan Shields

Establishing Rules for Self-Adhesion and Aggregation of N-Glycan Sugars Using Virus Glycan Shields

Nanoparticle Characterization of Traditional Homeopathically- Manufactured Gelsemium sempervirens Medicines and Placebo Controls

Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications

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