2013
DOI: 10.1369/0022155413501677
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Laminin and Type IV Collagen Isoform Substitutions Occur in Temporally and Spatially Distinct Patterns in Developing Kidney Glomerular Basement Membranes

Abstract: Kidney glomerular basement membranes (GBMs) undergo laminin and type IV collagen isoform substitutions during glomerular development, which are believed to be required for maturation of the filtration barrier. Specifically, GBMs of earliest glomeruli contain laminin α1β1γ1 and collagen α1α2α1(IV), whereas mature glomeruli contain laminin α5β2γ1 and collagen α3α4α5(IV). Here, we used confocal microscopy to simultaneously evaluate expression of different laminin and collagen IV isoforms in newborn mouse GBMs. Ou… Show more

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Cited by 34 publications
(31 citation statements)
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“…The increased synthesis of the ␣1 chain of collagen IV and the resumption of the production of perlecan in DN may indicate an embryonic stage of GBM synthesis (4). The change in the synthesis from the ␣1 and ␣2 chains to the ␣3, -4, and -5 chains of collagen IV as well as the change from perlecan to Fig.…”
Section: Discussionmentioning
confidence: 98%
“…The increased synthesis of the ␣1 chain of collagen IV and the resumption of the production of perlecan in DN may indicate an embryonic stage of GBM synthesis (4). The change in the synthesis from the ␣1 and ␣2 chains to the ␣3, -4, and -5 chains of collagen IV as well as the change from perlecan to Fig.…”
Section: Discussionmentioning
confidence: 98%
“…Mutations in the ˛3(IV), ˛4(IV), or ˛5(IV) genes cause Alport syndrome which is characterized by hematuria, glomerulonephritis, sensoneurinal and ocular abnormalities [78,79]. The switch between Laminin and Collagen IV isoforms does not occur simultaneously and therefore seems to be controlled by different mechanisms [80]. The reason for the developmental switch in Laminin and Collagen isoforms is not yet clear.…”
Section: Glomerular Basement Membranementioning
confidence: 99%
“…The increase correlated to the incorporation of these chains into the mature GBM collagen and laminin trimers during the capillary loop stage of glomerulogenesis. 88,90 Mutations in COL4A3-5 can yield Alport syndrome that manifests as glomerular hematuria, 86 while mutations in LAMB2 and LAMA5 yield nephrotic syndrome. 87,89 A common kidney matrisome was observed across multiple proteomic studies.…”
Section: Discussionmentioning
confidence: 99%