This study assessed landslide susceptibility in Shahpur valley, situated in the eastern Hindu Kush. Here, landslides are recurrent phenomena that disrupt the natural environment, and almost every year, they cause huge property damages and human losses. These damages are expected to escalate in the study area due to the high rate of deforestation in the region, population growth, agricultural expansion, and infrastructural development on the slopes. Landslide susceptibility was assessed by applying “weight of evidence” (WoE) and “information value” (IV) models. For this, the past landslide areas were identified and mapped on the SPOT5 satellite image and were verified from frequent field visits to remove the ambiguities from the initial inventory. Seven landslide contributing factors including surface geology, fault lines, slope aspect and gradient, land use, and proximity to roads and streams were identified based on indigenous knowledge and studied scientific literature. The relationship of landslide occurrence with contributing factors was calculated using WoE and IV models. The susceptibility maps were generated based on both the WoE and IV models. The results showed that the very high susceptible zone covered an area of 14.49% and 12.84% according to the WoE and IV models, respectively. Finally, the resultant maps were validated using the success and prediction rate curves, seed cell area index (SCAI), and R-index approaches. The success rate curve validated the results at 80.34% for WoE and 80.13% for the IV model. The calculated prediction rate for both WoE and IV was 83.34 and 85.13%, respectively. The SCAI results showed similar performance of both models in landslide susceptibility mapping. The result shows that the R-index value for the very high LS zone was 29.64% in the WoE model, and it was 31.21% for the IV model. Based on the elements at risk, a landslide vulnerability map was prepared that showed high vulnerability to landslide hazards in the lower parts of the valley. Similarly, the hazard and vulnerability maps were combined, and the risk map of the study area was generated. According to the landslide risk map, 5.5% of the study area was under high risk, while 2% of the area was in a very high-risk zone. It was found from the analysis that for assessing landslide susceptibility, both the models are suitable and applicable in the Hindu Kush region.