Language laterality in left-handers assessed by unilateral E.C.T.

Warrington, Elizabeth K.; Pratt, R. T. C.

doi:10.1016/0028-3932(73)90029-8

Cited by 119 publications

(49 citation statements)

References 4 publications

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“…There is also a weak correlation between handedness and the lateralized representation of language in the human brain. Studies based on the Wada test (Rasmussen & Milner 1977), electroconvulsive therapy (Warrington & Pratt 1973) and brain imaging (Pujol et al 1999;Knecht et al 2000) are reasonably consistent in showing that over 90 per cent of right-handers are left-cerebrally dominant for language, compared with approximately 70 per cent of left-handers. These estimates can be matched by McManus's model with p(D)Z0.8, on the assumption that handedness and cerebral dominance for language are subject to the same biases in the three genotypes, but that the biases are applied independently (table 2).…”

Section: Genetic Theoriesmentioning

confidence: 88%

The evolution and genetics of cerebral asymmetry

Corballis

2008

Phil. Trans. R. Soc. B

235

167

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Handedness and cerebral asymmetry are commonly assumed to be uniquely human, and even defining characteristics of our species. This is increasingly refuted by the evidence of behavioural asymmetries in non-human species. Although complex manual skill and language are indeed unique to our species and are represented asymmetrically in the brain, some non-human asymmetries appear to be precursors, and others are shared between humans and non-humans. In all behavioural and cerebral asymmetries so far investigated, a minority of individuals reverse or negate the dominant asymmetry, suggesting that such asymmetries are best understood in the context of the overriding bilateral symmetry of the brain and body, and a trade-off between the relative advantages and disadvantages of symmetry and asymmetry. Genetic models of handedness, for example, typically postulate a gene with two alleles, one disposing towards right-handedness and the other imposing no directional influence. There is as yet no convincing evidence as to the location of this putative gene, suggesting that several genes may be involved, or that the gene may be monomorphic with variations due to environmental or epigenetic influences. Nevertheless, it is suggested that, in behavioural, neurological and evolutionary terms, it may be more profitable to examine the degree rather than the direction of asymmetry.

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Section: Genetic Theoriesmentioning

confidence: 88%

The evolution and genetics of cerebral asymmetry

Corballis

2008

Phil. Trans. R. Soc. B

235

167

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“…Because familial sinistrality influenced the anatomical pattern in left-handers and planum temporale asymmetry is already present in the newborn, prenatal factors must play an important role in the development of functional laterality. [25], 25 to 85% of the sinistral population have an anomalous, that is, bilateral or right functional representation of language. This figure is at least 10-fold higher than in dextrals [22,[26][27][28].…”

mentioning

confidence: 99%

Anatomical left‐right asymmetry of language‐related temporal cortex is different in left‐ and right‐handers

Steinmetz

Volkmann

Jäncke

et al. 1991

Annals of Neurology

385

142

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Asymmetry of the planum temporale, a language-related intrasylvian area on the superior temporal gyrus, is the most remarkable anatomical left-right asymmetry of the human brain. The in vivo application of magnetic resonance morphometry in 52 healthy volunteers (26 dextrals and 26 sinistrals) revealed that planum temporale asymmetry is correlated with hand dominance. Left-handers had a significantly lesser degree of leftward planum temporale asymmetry than right-handers. Thus, a structural-functional relation exists in cerebral asymmetry. The correlation is likely to reflect language representation. Because familial sinistrality influenced the anatomical pattern in left-handers and planum temporale asymmetry is already present in the newborn, prenatal factors must play an important role in the development of functional laterality.

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“…Sindsdien kende het onderzoek naar afasiestoornissen een enorme vlucht. Verdere bewijsvoering vindt men in de onderzoeken van Sperry bij 'split brain' patie¨nten, de Sodium Amobarbital test, onderzoeken die gebruik maken van elektrofysiologische technieken en elektroshock-therapie (Warrington & Pratt, 1973), Voor een overzicht verwijzen we naar Springer en Deutch (1981).…”

Section: Functionele Asymmetrie Van De Hersenenunclassified

Lateralisatie en leerproblemen: de doolhof van Minos

Cracco¹

1992

Kind Adolesc.

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Lateralisatie en leerproblemen: de doolhof van Minos J. Cracco Samenvatting In dit artikel wordt het verband tussen leerproblemen en lateralisatie nader toegelicht. De term 'lateralisatie' blijkt vele ladingen te dekken. We kunnen verschillende niveaus onderscheiden: 1. lateralisatie in het gedrag, 2. het cognitief niveau, 3. functionele en 4. structurele asymmetriee¨n. Nadat de literatuurgegevens over deze verschillende niveaus werden nagegaan kom ik tot de conclusie dat de onderzoeken vaak tegenstrijdige resultaten opleveren en dikwijls lijden aan methodologische problemen. Verder blijkt dat 'lateralisatietheoriee¨n' te vaag zijn en te weinig gebaseerd op een grondige empirische bewijsvoering. Dit heeft implicaties voor de behandeling van kinderen met leerproblemen.

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Language laterality in left-handers assessed by unilateral E.C.T.

Cited by 119 publications

References 4 publications

The evolution and genetics of cerebral asymmetry

The evolution and genetics of cerebral asymmetry

Anatomical left‐right asymmetry of language‐related temporal cortex is different in left‐ and right‐handers

Lateralisatie en leerproblemen: de doolhof van Minos

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