Language Processing in Parkinson's Disease Patients Without Dementia

Colman, Katrien; Bastiaanse, Y.R.M.

doi:10.5772/18035

Cited by 11 publications

(9 citation statements)

References 116 publications

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“…It has been repeatedly shown that language functions in patients with PD are compromised even in patients without major cognitive impairment. 41 Patients with PD have problems with comprehension of syntactically complex sentences. 42 Therefore, we must also consider that these deficits in receptive language functions could influence how patients with PD interpret the test instructions and how they respond to the Hinting Task.…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Košutzká

Kŕaĺová

Kušnírová

et al. 2019

J Geriatr Psychiatry Neurol

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Objectives: Theory of Mind (ToM), the ability to understand other people’s mental states, is essential in everyday social interactions. The relationship between cognitive domains and ToM impairment in Parkinson disease (PD) has been receiving growing attention with ambiguous findings. The objective of the current study was to ascertain which cognitive domain predicts understanding of intentions and the impact of PD-specific clinical measures on ToM performance. A secondary aim was to evaluate whether cognitive impairment mediates the relationship between severity of illness and ToM impairment. Methods: Fifty-one nondemented patients with idiopathic PD, ranging from early to advanced stages, were enrolled. A comprehensive neurocognitive battery and 2 ToM tasks (Hinting Task and Comic Strip Task) were administered during the patients’ best “on” medication state. Results: Only the task of measuring working memory capacity was significantly associated with both ToM tasks (Hinting Task Spearman rank correlation [ rs] = 0.309, P ≤ .05; Comic Strip Task rs = 0.595, P ≤ .01). Patients with more progressed disease and higher doses of dopaminergic medication performed significantly worse in the Comic Strip Task. Based on the mediation analysis, relationship between the severity of the illness and understanding of intentions was mediated by cognitive flexibility. Conclusion: In PD, understanding of intentions is related to neurocognition, with working memory and cognitive flexibility playing a crucial role. The severity of PD predicts ToM performance.

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Section: Discussionmentioning

confidence: 99%

Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Košutzká

Kŕaĺová

Kušnírová

et al. 2019

J Geriatr Psychiatry Neurol

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“…Studies on the production of single words suggest that production processes in PD are relatively intact, but that there may be some problems in the control of these processes. Colman and Bastiaanse [ 44 ] performed a review of single word production in PD patients. The main findings of the review are as follows: verb and noun production tasks have shown impaired performance, with the former being more troublesome.…”

Section: Introductionmentioning

confidence: 99%

Verbal monitoring in Parkinson’s disease: A comparison between internal and external monitoring

et al. 2017

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Patients with Parkinson’s disease (PD) display a variety of impairments in motor and non-motor language processes; speech is decreased on motor aspects such as amplitude, prosody and speed and on linguistic aspects including grammar and fluency. Here we investigated whether verbal monitoring is impaired and what the relative contributions of the internal and external monitoring route are on verbal monitoring in patients with PD relative to controls. Furthermore, the data were used to investigate whether internal monitoring performance could be predicted by internal speech perception tasks, as perception based monitoring theories assume. Performance of 18 patients with Parkinson’s disease was measured on two cognitive performance tasks and a battery of 11 linguistic tasks, including tasks that measured performance on internal and external monitoring. Results were compared with those of 16 age-matched healthy controls. PD patients and controls generally performed similarly on the linguistic and monitoring measures. However, we observed qualitative differences in the effects of noise masking on monitoring and disfluencies and in the extent to which the linguistic tasks predicted monitoring behavior. We suggest that the patients differ from healthy subjects in their recruitment of monitoring channels.

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“…However, important questions about cognitive disorders in patients without dementia have yet to be addressed ( Barone et al, 2011 ). Research over the past two decades on the various processes specific to language impairment in PD (for reviews, see Murray, 2008 ; Altmann and Troche, 2011 ; Colman and Bastiaanse, 2011 ; Auclair-Ouellet et al, 2017 ) indicates that language disorders should be viewed as part of the spectrum of cognitive deficits in patients with PD without dementia, as also recommended by the Movement Disorder Society task force on cognitive impairment ( Litvan et al, 2011 ). For example, higher-level language processes have been shown to be impaired in patients with PD, affecting various aspects of language comprehension such as complex sentence structure understanding ( Lieberman et al, 1992 ; Lee et al, 2003 ; Hochstadt et al, 2006 ; Angwin et al, 2006a ), metaphor and ambiguous sentence comprehension ( Berg et al, 2003 ; Monetta and Pell, 2007 ), inference generation ( Monetta et al, 2008 ), and irony comprehension ( Monetta et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Inhibitory Mechanisms in Parkinson’s Disease: Evidence From Lexical Decision and Simple Reaction Time Tasks

Letanneux

Velay

Viallet

et al. 2021

Front. Hum. Neurosci.

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IntroductionAlthough the motor signs of Parkinson’s disease (PD) are well defined, nonmotor symptoms, including higher-level language deficits, have also been shown to be frequent in patients with PD. In the present study, we used a lexical decision task (LDT) to find out whether access to the mental lexicon is impaired in patients with PD, and whether task performance is affected by bradykinesia.Materials and MethodsParticipants were 34 nondemented patients with PD, either without (off) medication (n = 16) or under optimum (on) medication (n = 18). A total of 19 age-matched control volunteers were also recruited. We recorded reaction times (RTs) to the LDT and a simple RT (control) task. In each task, stimuli were either visual or auditory. Statistical analyses consisted of repeated-measures analyses of variance and Tukey’s HSD post hoc tests.ResultsIn the LDT, participants with PD both off and on medication exhibited intact access to the mental lexicon in both modalities. In the visual modality, patients off medication were just as fast as controls when identifying real words, but slower when identifying pseudowords. In the visual modality of the control task, RTs for pseudowords were significantly longer for PD patients off medication than for controls, revealing an unexpected but significant lexicality effect in patients that was not observed in the auditory modality. Performances of patients on medication did not differ from those of age-matched controls.DiscussionMotor execution was not slowed in patients with PD either off or on medication, in comparison with controls. Regarding lexical access, patients off medication seemed to (1) have difficulty inhibiting a cognitive-linguistic process (i.e., reading) when it was not required (simple reaction time task), and (2) exhibit a specific pseudoword processing deficit in the LDT, which may have been related to impaired lateral word inhibition within the mental lexicon. These deficits seemed to be compensated by medication.

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Language Processing in Parkinson's Disease Patients Without Dementia

Cited by 11 publications

References 116 publications

Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Neurocognitive Predictors of Understanding of Intentions in Parkinson Disease

Verbal monitoring in Parkinson’s disease: A comparison between internal and external monitoring

Altered Inhibitory Mechanisms in Parkinson’s Disease: Evidence From Lexical Decision and Simple Reaction Time Tasks

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